| 孙雨辉1，王春媛1，刘巾玮1▲，王东娜1，王旭梅1，陆景坤2，苏柯萌1，祁孟然1，梁凤娟1.基于网络药理学探讨特色蒙药山沉香治疗心肌缺血的作用机制[J].中国医药科学,2025,(5):57-60转118 基金项目:内蒙古自治区赤峰市自然科学科研立项课题（SZR2023090） |
| 基于网络药理学探讨特色蒙药山沉香治疗心肌缺血的作用机制 |
| Investigation on the function mechanism of the characteristic Mongolian medicine Syringa pinnatifolia in the treatment of myocardial ischemia based on network pharmacology |
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| DOI： |
| 中文关键词: 蒙药；山沉香；网络药理学；心肌缺血；作用机制 |
| 英文关键词:Mongolian medicine; Syringa pinnatifolia; Network pharmacology; Myocardial ischemia; Function mechanism |
| 作者 | 单位 | | 孙雨辉1，王春媛1，刘巾玮1▲，王东娜1，王旭梅1，陆景坤2，苏柯萌1，祁孟然1，梁凤娟1 | 1.内蒙古自治区赤峰市医院药剂科，内蒙古赤峰 024000；2.内蒙古医科大学基础医学院，内蒙古呼和浩特 010030 |
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| 中文摘要: |
| [摘要] 目的 探讨特色蒙药山沉香治疗心肌缺血的分子作用机制。 方法 通过文献挖掘、数据库检索收集山沉香的化学成分，利用SWISS、Superpred等在线平台进行目标化合物的靶标预测。应用OMIM数据库检索并整理心肌缺血有关疾病及发病机制相关靶标，利用EVenn在线作图工具制作Venn图，获取山沉香活性成分靶标基因与心肌缺血相关靶标基因的交叉靶标，即关键靶标。经DAVID 数据库对山沉香的关键靶标进行靶标功能富集分析，筛选与心肌缺血相关的信号通路，同时绘制生信图使结果可视化。并采用Cytoscape软件构建“化合物-关键靶标-信号通路”网络模型，应用Schrodinger程序对山沉香活性成分与关键靶标进行分子对接验证。 结果 共收集山沉香活性成分55个，预测化合物靶标1394个，心肌缺血疾病及发病机制靶标1022个，化合物与疾病交叉靶标132个。网络药理学结果显示，山沉香与心肌缺血疾病相关的生物学途径可能有炎性反应、应激反应、细胞凋亡、动脉粥样硬化、内分泌调节等。PI3K-Akt信号通路可能是山沉香发挥药效治疗心肌缺血的主要作用通路。 结论 山沉香可能是通过炎性反应、应激反应、细胞凋亡、动脉粥样硬化、内分泌调节等途径发挥治疗心肌缺血的作用。 |
| 英文摘要: |
| [Abstract] Objective To investigate the molecular function mechanism of the characteristic Mongolian medicine Syringa pinnatifolia in the treatment of myocardial ischemia. Methods The chemical components of Syringa pinnatifolia were collected through literature mining and database retrieval, and target prediction of target compounds was performed using online platforms such as SWISS and Superpred. Targets related to myocardial ischemia relevant diseases and pathogenesis using the OMIM database were retrieved and organized, and Venn maps using the EVenn online mapping tool were created to obtain cross targets between the active ingredient target genes of Syringa pinnatifolia and the myocardial ischemia related target genes, namely key targets. Target function enrichment analysis was performed on key targets of Syringa pinnatifolia using the DAVID database, signaling pathways related to myocardial ischemia were screened, and the results by drawing a bioinformatics diagram were visualized. A network model of "compound - key target - signal pathway" was constructed using Cytoscape software, and the Schrodinger program was used to perform molecular docking verification between the active ingredients of Syringa pinnatifolia and key targets. Results A total of 55 active ingredients from Aquilaria sinensis were collected, with 1,394 predicted compound targets, 1,022 targets for myocardial ischemia disease and its pathogenesis, and 132 cross targets between compounds and diseases. The results of network pharmacology showed that the biological pathways of Syringa pinnatifolia related to myocardial ischemia disease might include inflammatory reaction, stress reaction, apoptosis, atherosclerosis, endocrine regulation, etc. The PI3K-Akt signaling pathwaymay be the main pathway through which Syringa pinnatifolia exerts its pharmacological effects in the treatment of myocardial ischemia. Conclusion Aquilaria sinensis may play a role in the treatment of myocardial ischemia through inflammatory reaction, stress reaction, apoptosis, atherosclerosis, endocrine regulation, etc. |
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