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蔡仁杰,彭素娟▲.肺力咳合剂联合盐酸氨溴索治疗支气管扩张伴感染的临床效果[J].中国医药科学,2025,(4):114-118        基金项目:
肺力咳合剂联合盐酸氨溴索治疗支气管扩张伴感染的临床效果
Clinical effect of Feilike Mixture combined with ambroxol hydrochloride in the treatment of bronchiectasis with infection
  
DOI:
中文关键词:  肺力咳合剂;盐酸氨溴索;支气管扩张;感染
英文关键词:Feilike Mixture; Ambroxol hydrochloride; Bronchiectasis; Infection
作者单位
蔡仁杰,彭素娟▲ 湖南中医药大学第二附属医院呼吸与危重症医学科,湖南长沙 410000 
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中文摘要:
      [摘要] 目的 研究肺力咳合剂联合盐酸氨溴索治疗支气管扩张伴感染的临床效果。 方法 选取2021年7月至2023年2月湖南中医药大学第二附属医院呼吸与危重症医学科诊治的114例支气管扩张伴感染患者作为研究对象,使用密封信封法将其随机分为两组,对照组57例患者给予盐酸氨溴索治疗;观察组57例患者给予肺力咳合剂联合盐酸氨溴索治疗。比较两组中性粒细胞百分比、肺功能、血清指标及各项临床症状。 结果 治疗后,两组咳嗽、咳痰、胸闷痛、口干、喘息、痰中带血、湿啰音症状评分均降低,且观察组低于对照组,差异有统计学意义(P < 0.05)。治疗后,两组痰液和外周血中性粒细胞百分比、血管细胞黏附分子-1和可溶性细胞间黏附分子-1含量均降低,且观察组降低更明显,差异有统计学意义(P < 0.05)。治疗后,两组第1秒用力呼气容积(FEV1)、FEV1/用力肺活量和最大呼气中段流量均升高,且观察组升高更明显,差异有统计学意义(P < 0.05)。 结论 肺力咳合剂联合盐酸氨溴索协同作用,可有效缓解支气管扩张伴感染患者的各项临床症状,减轻炎症反应,提高肺功能,临床应用价值高。
英文摘要:
      [Abstract] Objective To investigate the clinical effect of Feilike Mixture combined with ambroxol hydrochloride in the treatment of bronchiectasis with infection. Methods A total of 114 patients with bronchiectasis with infection diagnosed and treated in the Department of Respiratory and Critical Care Medicine of the Second Affiliated Hospital of Hunan University of Chinese Medicine from July 2021 to February 2023 were selected as the study subjects. They were randomly divided into two groups using the sealed-envelope method. 57 patients in the control group were given ambroxol hydrochloride. 57 patients in the observation group were given Feilike Mixture combined with ambroxol hydrochloride. The neutrophil percentage, pulmonary function, serum indexes and various clinical symptoms were compared between the two groups. Results After treatment, the symptom scores of cough, sputum, chest distress, dry mouth, wheezing, bloody sputum and moist rales were reduced in both groups, and they were lower in the observation group than those of the control group, with statistically significant differences (P < 0.05). After treatment, the sputum, peripheral blood neutrophil percentage and the content of vascular cell adhesion molecule-1 and soluble intercellular adhesion molecule-1 were reduced in both groups, and the reduction was more pronounced in the observation group, with statistically significant differences (P < 0.05). After treatment, the forced expiratory volume in one second (FEV1), FEV1/forced vital capacity and maximal mid-expiratory flow increased in both groups, and the increase was more pronounced in the observation group, with statistically significant differences (P < 0.05). Conclusion The synergistic effect of Feilike Mixture combined with ambroxol hydrochloride can effectively alleviate various clinical symptoms of patients with bronchiectasis with infection, reduce the inflammatory response and improve the pulmonary function, which is of high clinical application value.
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关键词: 中国医药科学 中国医学 中国医学科学 中华医学 医学杂志 临床医学杂志 医学期刊 中国预防医学 中华预防医学 预防医学杂志 中国药学 药学杂志
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