| 郭丰宁，王暖▲.MAPK/CREB信号通路及CD40-1C/T基因多态性对缺血性脑卒中后癫痫易感性的影响[J].中国医药科学,2025,(4):90-93 基金项目:江苏省卫生健康委科研项目（Z2023062） |
| MAPK/CREB信号通路及CD40-1C/T基因多态性对缺血性脑卒中后癫痫易感性的影响 |
| Impacts of MAPK/CREB signal pathway and CD40-1C/T gene polymorphism on epilepsy susceptibility after ischemic stroke |
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| DOI： |
| 中文关键词: p38丝裂原活化蛋白激酶；cAMP反应元件结合蛋白；CD40；缺血性脑卒中；癫痫 |
| 英文关键词:p38 mitogen-activated protein kinase; cAMP response element binding protein; CD40; Ischemic stroke; Epilepsy |
| 作者 | 单位 | | 郭丰宁，王暖▲ | 徐州医科大学附属徐州市立医院神经内科，江苏徐州 221100 |
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| 中文摘要: |
| [摘要] 目的 探讨p38丝裂原活化蛋白激酶/cAMP 反应元件结合蛋白（p38MAPK/CREB）及CD40基因非编码区Kozak序列-1位点的C/T（CD40-1C/T）基因多态性对缺血性脑卒中后癫痫易感性的影响。 方法 选取2020年2月至2023年6月徐州医科大学附属徐州市立医院收治的280例缺血性脑卒中患者，其中继发性癫痫140例（癫痫组），无继发性癫痫140例（对照组）。比较两组的p38MAPK、p-CREB磷酸化水平和CD40-1C/T基因多态性差异。 结果 癫痫组的p38MAPK、p-CREB磷酸化水平高于对照组（P < 0.05）；癫痫组的TT基因型和T等位基因频率高于对照组，CC基因型频率低于对照组（P < 0.05）；logistic回归分析显示，p38MAPK磷酸化水平、p-CREB磷酸化水平、CC基因型频率、TT基因型频率、T等位基因频率、出血性转化、美国国立卫生研究院卒中量表（NIHSS）评分、病灶大小是缺血性脑卒中后癫痫的影响因素。 结论 缺血性脑卒中患者出现癫痫与p38MAPK/CREB信号通路有关，而TT基因型频率、T等位基因频率可能增加了缺血性脑卒中后癫痫患者的易感性。 |
| 英文摘要: |
| [Abstract] Objective To investigate the impacts of p38 mitogen-activated protein kinase/cAMP response element binding protein (p38MAPK/CREB) and C/T of Kozak Sequence-1 Site in Non-coding Region of CD40 Gene (CD40-1C/T) gene polymorphism on epilepsy susceptibility after ischemic stroke. Methods Patients with ischemic stroke admitted to and treated in the Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University from February 2020 to June 2023 were selected, and they were divided into the epilepsy group (n=140, including patients with secondary epilepsy) and the control group (n=140, including patients without secondary epilepsy). p38MAPK, p-CREB phosphorylation level and CD40-1C/T gene polymorphism were compared between the two groups. Results The phosphorylation levels of p38MAPK and p-CREB in the epilepsy group were higher than those in the control group, with statistically significant differences (P < 0.05). The frequencies of TT genotype and T allele in the epilepsy group were higher than those in the control group, while the frequencies of CC genotype were lower than those in the control group, with statistically significant differences (P < 0.05). Logistic regression analysis showed that p38MAPK phosphorylation level, p-CREB phosphorylation level, CC genotype frequency, TT genotype frequency, T allele frequency, hemorrhagic transformation, National Institutes of Health Stroke Scale (NIHSS) score and lesion size were the impacting factors of epilepsy after ischemic stroke. Conclusion Epilepsy in patients with ischemic stroke is related to p38MAPK/CREB signaling pathway, while TT genotype frequency and T allele frequency may increase the susceptibility of patients with epilepsy after ischemic stroke. |
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