| 王俊文1，于波1，刘薇1，高慧双1，田淑琳2，路璐1，朱雅迪1， 宁永忠1.北京市垂杨柳医院患者γ-干扰素释放试验的临床应用研究[J].中国医药科学,2025,(2):134-137 基金项目:北京市科技攻关计划（首发2021-1G-2032） |
| 北京市垂杨柳医院患者γ-干扰素释放试验的临床应用研究 |
| Clinical application research of interferon gamma release assay of patients in Chuiyangliu Hospital of Beijing City |
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| DOI： |
| 中文关键词: γ-干扰素释放试验；潜伏结核感染；结核分枝杆菌；结核病；结核菌素皮肤试验 |
| 英文关键词:Interferon gamma release assay; Latent tuberculosis infection; Mycobacterium tuberculosis; Tuberculosis; Tuberculin skin test |
| 作者 | 单位 | | 王俊文1，于波1，刘薇1，高慧双1，田淑琳2，路璐1，朱雅迪1， 宁永忠1 | 1.北京市垂杨柳医院检验科，北京 100022；2.河北医科大学研究生院，河北石家庄 050017 |
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| 中文摘要: |
| [摘要] 目的 了解北京市垂杨柳医院就诊患者γ-干扰素释放试验（IGRA）检测结核分枝杆菌潜伏感染临床特征。 方法 收集北京市垂杨柳医院2018年1月至2022年12月的8736例患者IGRA检测结果，分析患者潜在感染状况。 结果 就诊患者IGRA总阳性率为17.26%（1508/8736），2018—2022年逐年比较，差异有统计学意义（χ2=13.706，P=0.008）。男性组IGRA总阳性率高于女性组，差异有统计学意义（χ2=5.168，P=0.012）。4个年龄组阳性率比较，差异有统计学意义（χ2=6.951，P=0.001），年龄越大IGRA阳性率越低。 结论 北京市垂杨柳医院就诊患者结核杆菌潜伏感染相对较高，有逐年增高趋势，提示应加强人员监测力度，提高结核分枝杆菌潜伏感染的早期诊断率。 |
| 英文摘要: |
| [Abstract] Objective To understand the clinical characteristics of detecting latent infection of Mycobacterium tuberculosis by interferon gamma release assay (IGRA) of patients in Chuiyangliu Hospital of Beijing City. Methods The IGRA test results of 8736 patients in Chuiyangliu Hospital of Beijing City from January 2018 to December 2022 were collected, and the potential infection status of patients was analyzed. Results The total positive rate of IGRA in visiting patients was 17.26% (1508/8736), and the difference was statistically significant from 2018 to 2022 (χ2=13.706, P=0.008). The total positive rate of IGRA of male group was higher than the female group, with statistically significant difference (χ2=5.168, P=0.012). The positive rates of IGRA of the 4 age groups were compared, with statistically significant difference (χ2=6.951, P=0.001). The older the age group, the lower the positive rate. Conclusion The latent infection of Mycobacterium tuberculosis in patients admitted to Chuiyangliu Hospital of Beijing City is relatively high, which tends to increase year by year, suggesting that personnel monitoring should be strengthened to improve the early diagnosis rate of latent infection of Mycobacterium tuberculosis. |
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