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李音音,张巧云,刘云识,覃凤娴,邹燕,吴昊▲.D-二聚体和血小板在肝硬化中的诊断价值[J].中国医药科学,2024,14(11):150-153        基金项目:广西壮族自治区卫生健康委员会科研课题(Z20190002)
D-二聚体和血小板在肝硬化中的诊断价值
Diagnostic value of D-dimer and platelet in liver cirrhosis
  
DOI:
中文关键词:  肝硬化;乙型肝炎;D-二聚体;血小板
英文关键词:Liver cirrhosis; Hepatitis B; D-dimer; Platelets
作者单位
李音音,张巧云,刘云识,覃凤娴,邹燕,吴昊▲ 广西壮族自治区柳州市工人医院医学检验科,广西柳州 545000 
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中文摘要:
      [摘要]目的 探讨D-二聚体和血小板在肝硬化诊断中的价值。方法 选择2018年1月至2022年12月柳州市工人医院收治的肝硬化患者60例作为肝硬化组,将肝硬化组分为肝硬化代偿期组和肝硬化失代偿期组,乙肝表面抗原阳性组和乙肝表面抗原阴性组,另选取同期本院体检健康者60名为对照组,检测并分析D-二聚体和血小板。结果 肝硬化组D-二聚体水平高于对照组,差异有统计学意义(P < 0.05);肝硬化组血小板水平低于对照组,差异有统计学意义(P < 0.05)。乙肝表面抗原阳性组D-二聚体水平低于乙肝表面抗原阴性组,差异无统计学意义(P > 0.05);乙肝表面抗原阳性组血小板水平高于乙肝表面抗原阴性组,差异无统计学意义(P > 0.05)。肝硬化失代偿期组D-二聚体水平高于肝硬化代偿期组,差异有统计学意义(P < 0.05);肝硬化失代偿期组血小板水平低于肝硬化代偿期组,差异无统计学意义(P > 0.05)。结论 D-二聚体和血小板对于肝硬化诊断具有重要意义。
英文摘要:
      [Abstract] Objective To investigate the value of D-dimer and platelet in the diagnosis of liver cirrhosis. Methods A total of 60 patients with liver cirrhosis admitted to Liuzhou Workers’ Hospital from January 2018 to December 2022 were collected as liver cirrhosis group, and the liver cirrhosis group was divided into two groups, namely, the compensatory stage of liver cirrhosis group and the decompensated stage of liver cirrhosis group, the positive hepatitis B surface antigen group and the negative hepatitis B surface antigen group. At the same time, A total of 60 healthy people in the hospital were selected as the control group, and D-dimer and platelets were detected and analyzed. Results The level of D-dimer in liver cirrhosis group was higher than that in control group, the difference was statistically significant (P < 0.05), and the level of platelet in liver cirrhosis group was smaller than that in control group, the difference was statistically significant (P < 0.05). The level of D-dimer in the hepatitis B surface antigen positive group was smaller than that in the hepatitis B surface antigen negative group, with no statistically significant difference (P > 0.05). The level of platelets in hepatitis B surface antigen positive group were larger than those in hepatitis B surface antigen negative group, with no statistically significant difference (P > 0.05). The level of D-dimer in decompensated stage of liver cirrhosis group was higher than that in compensatory stage of liver cirrhosis group, and the difference was statistically significant (P < 0.05). The level of platelets in decompensated stage group were smaller than those in compensated stage group, and the difference was not statistically significant (P > 0.05). Conclusion D-dimer and platelets are of great significance for the diagnosis of liver cirrhosis.
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