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杨明妍1,毕峰2▲,吴雪姣3.高同型半胱氨酸血症合并脑梗死的临床疗效观察和药学监护[J].中国医药科学,2024,14(9):135-138        基金项目:吉林省四平市科技发展计划项目(2018002)
高同型半胱氨酸血症合并脑梗死的临床疗效观察和药学监护
Clinical efficacy observation and pharmaceutical monitoring of hyperhomocysteinemia combined with cerebral infarction
  
DOI:
中文关键词:  高同型半胱氨酸血症;脑梗死;临床药师;药学监护
英文关键词:Hyperhomocysteinemia; Cerebral infarction; Clinical pharmacists; Pharmaceutical monitoring
作者单位
杨明妍1,毕峰2▲,吴雪姣3 1.海南省安宁医院药剂科,海南海口 570207;2.海南省安宁医院神经内科,海南海口 570207;3.吉林省神经精神病医院临床药学室,吉林四平 136000 
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中文摘要:
      [摘要] 目的 分析高同型半胱氨酸血症合并脑梗死患者应用维生素B6、维生素B12、叶酸治疗的临床效果及药学应用价值。 方法 选取2021年6月至2022年12月在吉林省神经精神病医院就诊的106例高同型半胱氨酸血症合并脑梗死患者,按随机数表法分为对照组和观察组,每组各53例。观察组患者服用维生素B6、维生素B12、叶酸并进行药学监护,对照组采用常规治疗,分析两组患者治疗前及用药2个月后的临床疗效、颈动脉和下肢动脉影像学结果、同型半胱氨酸、叶酸、维生素B12水平以及用药后的不良反应。 结果 治疗前,两组患者的颈动脉和下肢动脉影像学结果、同型半胱氨酸、维生素B12、叶酸水平比较,差异无统计学意义(P > 0.05)。在药学监护后,观察组患者的临床总有效率高于对照组,颈动脉和下肢动脉内膜中层厚度与内膜斑块面积均低于对照组,同型半胱氨酸水平低于对照组,叶酸、维生素B12的水平均高于对照组,差异有统计学意义(P < 0.05)。观察组患者在用药期间有出现轻度胃肠道反应患者3例、过敏反应1例、肝功能异常1例,对照组出现轻度胃肠道反应4例、过敏反应2例、肝功能异常1例,两组患者用药不良反应总发生率比较,差异无统计学意义(P > 0.05)。在医师与药师的指导下,两组不良反应均好转。 结论 临床药师针对高同型半胱氨酸血症合并脑梗死的患者实施药学服务,采用维生素B6、维生素B12、叶酸治疗方案,具有良好的临床疗效,同时可以保证患者的用药安全,证实此方案具备良好的药学服务价值。
英文摘要:
      [Abstract] Objective To analyze the clinical efficacy and pharmaceutical application value of using vitamin B6, vitamin B12, and folic acid to treat patients with hyperhomocysteinemia combined with cerebral infarction. Methods A total of 106 patients with hyperhomocysteinemia combined with cerebral infarction who were treated at Jilin Neuropsychiatric Hospital from June 2021 to December 2022 were selected and divided into a control group and an observation group by random number table method, with 53 patients in each group. The patients in the observation group took vitamin B6, vitamin B12, and folic acid with pharmaceutical monitoring, while the control group received routine treatment. The clinical efficacy, carotid, and lower limb artery imaging findings, levels of homocysteine, folic acid, and vitamin B12, as well as adverse reactions after medication before and 2 months after treatment were analyzed in both groups. Results Before treatment, there were no statistically significant differences in the imaging findings of the carotid and lower limb arteries, as well as the levels of homocysteine, folic acid, and vitamin B12 between the two groups (P > 0.05). After pharmaceutical services, the total clinical effective rate of patients in the observation group was higher than that in the control group. The thickness of the intima-media and the area of intima plaques in the carotid and lower limb arteries were lower than those in the control group, and the level of homocysteine was lower than that in the control group, the levels of folic acid, and vitamin B12 were higher than those in the control group, with statistically significant differences (P < 0.05). During the medication period, 3 patients in the observation group experienced mild gastrointestinal reactions, 1 patient had abnormal liver function, and 1 patient had allergic reactions, and there was no statistically significant difference in the total incidence of adverse drug reactions between the two groups of patients (P > 0.05). In the control group, 4 patients had mild gastrointestinal reactions, 1 patient had abnormal liver function, and 2 patients had allergic reactions. Under the guidance of physicians and pharmacists, both groups showed improvement in adverse reactions. Conclusion The use of vitamin B6, vitamin B12, and folic acid treatment regimen provided in pharmaceutical services by clinical pharmacists for patients with hyperhomocysteinemia complicated with cerebral infarction has good clinical therapeutic effects while ensuring medication safety, confirming that this regimen has good pharmaceutical service value.
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关键词: 中国医药科学 中国医学 中国医学科学 中华医学 医学杂志 临床医学杂志 医学期刊 中国预防医学 中华预防医学 预防医学杂志 中国药学 药学杂志
药理杂志 中国中医 中医杂志 中华中医药 中医药杂志 中国医疗 医疗器械杂志 中国中西医结合 中国医药 医药杂志 医药期刊 医药论文 医学论文 科研论文 职称论文
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