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彭秀娟1,张丹凤2▲.真核翻译起始因子4G1与恶性肿瘤的研究进展[J].中国医药科学,2024,14(9):31-35        基金项目:黑龙江省卫生健康委科研课题(20210505010040)
真核翻译起始因子4G1与恶性肿瘤的研究进展
Research progress of eukaryotic translation initiation factor 4G1 and malignant tumor
  
DOI:
中文关键词:  真核翻译起始因子4G1;帽依赖性翻译;真核翻译起始因子;肿瘤;mRNA
英文关键词:Eukaryotic translation initiation factor 4 gamma 1; Cap-dependent translation; Eukaryotic translation initiation factor; Tumor; mRNA
作者单位
彭秀娟1,张丹凤2▲ 1.佳木斯大学临床医学院,黑龙江佳木斯 154000;2.佳木斯大学附属第一医院妇产科,黑龙江佳木斯 154000 
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中文摘要:
      [摘要] 真核翻译起始因子4G1(eIF4G1)是一种大型支架蛋白,在真核生物mRNA翻译起始过程中,可作为蛋白质的对接位点,介导帽依赖性与非帽依赖性翻译启动。eIF4G1是翻译调控中的重要靶标,被认为参与多种肿瘤细胞的生长、迁移、增殖、侵袭和凋亡。近年来,随着对eIF4G1研究的深入,临床对其作用和功能也有了更深的理解,本文总结相关文献,对eIF4G1的功能、研究现状及与肿瘤的关系做一简要综述。
英文摘要:
      [Abstract] Eukaryotic translation initiation factor 4 gamma 1 (eIF4G1) is a large scaffold protein, which can serve as a docking site for proteins during mRNA translation initiation of eukaryotes, and mediate cap-dependent and cap-independent translation initiation. eIF4G1 is an important target in translation regulation, which is considered to be involved in the growth, migration, proliferation, invasion and apoptosis of various tumor cells. In recent years, with the in-depth study of eIF4G1, we have a deeper understanding of its effects and functions. This article will summarize the relevant literature, and briefly summarize the function, research status and relationship with tumors of eIF4G1.
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