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张志俊.兰术化浊汤对糖调节受损脂代谢及氧化应激的影响[J].中国医药科学,2024,14(9):22-25        基金项目:山西中医药大学附属医院青年基金培育项目(QN202105)
兰术化浊汤对糖调节受损脂代谢及氧化应激的影响
Influence of Lanzhu Huazhuo Decoction on lipid metabolism and oxidative stress caused by impaired glucose regulation
  
DOI:
中文关键词:  糖调节受损;兰术化浊汤;脂代谢;氧化应激
英文关键词:Impaired glucose regulation; Lanzhu Huazhuo Decoction; Lipid metabolism; Oxidative stress
作者单位
张志俊 山西中医药大学附属医院内分泌科,山西太原 030024 
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中文摘要:
      [摘要] 目的 探讨兰术化浊汤对糖调节受损脂代谢及氧化应激的影响。 方法 36只SD雄性大鼠,将其中30只构建糖调节受损大鼠模型,造模成功后,30只大鼠随机分为模型组、二甲双胍组(200 mg/kg)、兰术化浊汤低剂量组(5 g/kg)、兰术化浊汤中剂量组(10 g/kg)、兰术化浊汤高剂量组(20 g/kg),每组各6只,另6只设为空白组。治疗组分别按不同剂量灌胃给药,模型组与空白组按1 ml/100 g生理盐水灌胃,1次/d,连续4周。通过尾尖采血的方式检测空腹血糖(FBG)、糖耐量试验2 h血糖(OGTT2hPG),测量各组大鼠体重,生化分析血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平,试剂盒检测血清丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)水平。 结果 与空白组比较,模型组大鼠体重、HDL-C、SOD、GSH-PX水平降低,FBG、OGTT2hPG、TC、TG、LDL-C、MDA水平升高,差异有统计学意义(P < 0.05);与模型组比较,兰术化浊汤中、高剂量组大鼠体重、HDL-C、SOD、GSH-PX水平升高,FBG、OGTT2hPG、TC、TG、LDL-C、MDA水平降低,差异有统计学意义(P < 0.05)。 结论 兰术化浊汤可有效调节脂质代谢和氧化应激,从而改善糖调节受损。
英文摘要:
      [Abstract] Objective To investigate the influence of Lanzhu Huazhuo Decoction on lipid metabolism and oxidative stress caused by impaired glucose regulation. Methods A total of 30 in the 36 SD male rats were used to establish rat models with impaired glucose regulation. After successful modeling, the 30 rats were randomly divided into the model group (n=6), the metformin group (n=6, 200 mg/kg), the low-dose Lanzhu Huazhuo Decoction group (n=6, 5 g/kg), the middle-dose Lanzhu Huazhuo Decoction group (n=6, 10 g/kg) and the high-dose Lanzhu Huazhuo Decoction group (n=6, 20 g/kg). The other 6 rats were set as the blank group. The treatment groups were administered at different doses by gavage, while the model group and the blank group were administered with 1 ml/100 g physiological saline once a day for 4 consecutive weeks. Fasting blood glucose (FBG) and oral glucose tolerance test 2 h plasma glucose (OGTT2hPG) were measured by tail tip blood sampling, and the body weight of rats in each group was measured. Serum levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were analyzed biochemically, and serum levels of malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were detected using a reagent kit. Results Compared with the blank group, the body weight of rats, and the levels of HDL-C, SOD and GSH-Px in the model group decreased, while the levels of FBG, OGTT2hPG, TC, TG, LDL-C and MDA increased, with statistically significant differences (P < 0.05). Compared with the model group, the body weight of the rats, and the levels of HDL-C, SOD and GSH-Px in the middle-dose and high-dose groups of Lanzhu Huazhuo Decoction increased, while the levels of FBG, OGTT2hPG, TC, TG, LDL-C and MDA decreased, with statistically significant differences (P < 0.05). Conclusion Lanzhu Huazhuo Decoction can effectively regulate lipid metabolism and oxidative stress, thus improving impaired glucose regulation.
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