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游庭活1,赵伟志1,陈周全1,张辉2,段康1,张莉梅2▲.基于指纹图谱研究的山豆根药材、饮片、标准汤剂、配方颗粒比较研究[J].中国医药科学,2024,14(9):13-17        基金项目:广东省深圳市科技计划项目(JSGG20191129093418578)
基于指纹图谱研究的山豆根药材、饮片、标准汤剂、配方颗粒比较研究
Comparative study on medicinal materials, decoction pieces, standard decoction and formula granules of Radix Sophorae Tonkinensis based on fingerprint research
  
DOI:
中文关键词:  山豆根;标准汤剂;指纹图谱;配方颗粒;化学模式识别
英文关键词:Radix Sophorae Tonkinensis; Standard decoction; Fingerprint; Formula granules; Chemical pattern recognition
作者单位
游庭活1,赵伟志1,陈周全1,张辉2,段康1,张莉梅2▲ 1.华润三九现代中药制药有限公司,广东惠州 516000;2.华润三九医药股份有限公司,广东深圳 518110 
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中文摘要:
      [摘要] 目的 研究山豆根药材、饮片、标准汤剂、配方颗粒的主要成分检测方法,为山豆根配方颗粒的应用提供参考。 方法 通过高效液相色谱建立山豆根药材、饮片、标准汤剂、配方颗粒指纹图谱检测方法,利用相似度评价、相关性分析、聚类分析及主成分分析进行评价和分析。 结果 山豆根药材、饮片、标准汤剂和配方颗粒的指纹图谱色谱中均有5个共有特征峰,且全部指认;相似度评价及化学模式识别研究表明四者无明显的差异。 结论 山豆根药材、饮片、标准汤剂和配方颗粒的主要组成成分基本一致,可为山豆根配方颗粒的基础研究及临床应用研究提供参考。
英文摘要:
      [Abstract] Objective To study the detection methods of main components in medicinal materials, decoction pieces, standard decoction and formula granules of Radix Sophorae Tonkinensis, so as to provide reference for the application of Radix Sophorae Tonkinensis formula granules. Methods HPLC was used to establish a fingerprint detection method for medicinal materials, decoction pieces, standard decoction and formula granules of Radix Sophorae Tonkinensis, and similarity evaluation, correlation analysis, cluster analysis and main component analysis were used for evaluation and analysis. Results There were five common characteristic peaks in the fingerprint chromatograms for medicinal materials, decoction pieces, standard decoction and formula granules of Radix Sophorae Tonkinensis, all of which were identified. Similarity evaluation and chemical pattern recognition research showed that there was no obvious difference between the four kinds. Conclusion The main components of medicinal materials, decoction pieces, standard decoction and formula granules of Radix Sophorae Tonkinensis are basically the same, which can provide reference for the basic research and clinical application research for formula granules of Radix Sophorae Tonkinensis.
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