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邵晶1,陈红霞1,吕书勤2▲.基于“微生物-肠道-脑轴”理论探讨中药防治阿尔茨海默病的研究进展[J].中国医药科学,2024,14(7):46-50        基金项目:省部共建中亚高发病成因与防治国家重点实验室开放课题(SKL-HIDCA-2024-SZY3)
基于“微生物-肠道-脑轴”理论探讨中药防治阿尔茨海默病的研究进展
Research progress on the prevention and treatment of Alzheimer’s disease using traditional Chinese medicine based on the theory of the "microorganism-gut microbiota-brain axis"
  
DOI:
中文关键词:  阿尔茨海默病;肠道菌群;肠道-脑轴;中医药
英文关键词:Alzheimer’s disease; Gut flora; Gut microbiota-brain axis; Traditional Chinese medicine
作者单位
邵晶1,陈红霞1,吕书勤2▲ 1.乌鲁木齐市中医医院,新疆乌鲁木齐 830000;2.新疆医科大学第四临床医学院,新疆乌鲁木齐 830000 
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中文摘要:
      [摘要] 阿尔茨海默病(AD)是一种较为常见的严重危害健康的慢性神经退行性疾病,其以进行性认知功能障碍、行为损害为主要临床表现,具有不可逆性和致死性。其多发病于老年时期,且病程较长,无法彻底治愈,严重威胁人类的健康与发展。其发病机制尚未完全阐明,近年来诸多研究显示,“微生物-肠道-脑轴”在中枢神经系统中的作用引起了普遍关注,中枢神经系统与肠神经系统之间由“微生物-肠道-脑轴”形成双向传导通路,联系着大脑与肠道。肠道菌群失调可通过“肠道-脑轴”改变脑的正常功能,与AD疾病的发生发展有密切的关联。本文系统阐述了中医药基于“肠道-脑轴”理论调节肠道菌群防治AD的研究进展,为中医药防治AD提供新视角。
英文摘要:
      [Abstract] Alzheimer’s disease (AD) is a common chronic neurodegenerative disease that poses a serious threat to health. Its main clinical manifestations include progressive cognitive impairment and behavioral impairment, which are irreversible and fatal. It often occurs in the elderly and has a long course, and it cannot be completely cured, posing a serious threat to human health and development. The pathogenesis of this disease has not been fully elucidated. In recent years, many studies have shown that the role of the "microorganism-gut microbiota-brain axis" in the central nervous system has attracted widespread attention. The "microorganism-gut microbiota-brain axis" forms a bidirectional conduction pathway between the central nervous system and the enteric nervous system, connecting the brain and gut microbiota. Dysfunction of gut flora can alter normal brain function through the "gut microbiota-brain axis", which is closely related to the occurrence and development of AD. This paper systematically elaborates on the research progress of traditional Chinese medicine in regulating gut flora in the prevention and treatment of Alzheimer’s disease based on the "gut microbiota-brain axis" theory, providing a new perspective for the prevention and treatment of Alzheimer’s disease with traditional Chinese medicine.
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