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刘小荣1,杨国清2,梁文强2,张玉娟1,张鹏飞1,张静1,章晓波3,王勇平2▲.新型镁合金对金黄色葡萄球菌生物学特性影响的体外研究[J].中国医药科学,2024,14(7):8-11        基金项目:甘肃省兰州市科技计划项目(2021-1-79)
新型镁合金对金黄色葡萄球菌生物学特性影响的体外研究
In vitro study on the effect of a new magnesium alloy on the biological characteristics of Staphylococcus aureus
  
DOI:
中文关键词:  镁合金;金黄色葡萄球菌;生物学特性;生物膜
英文关键词:Magnesium alloy; Staphylococcus aureus; Biological characteristics; Biofilm
作者单位
刘小荣1,杨国清2,梁文强2,张玉娟1,张鹏飞1,张静1,章晓波3,王勇平2▲ 1.甘肃省第二人民医院检验科,甘肃兰州 730000;2.兰州大学第一医院骨科, 甘肃兰州 730000;3.南京工程学院材料工程学院,江苏南京 211167 
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中文摘要:
      [摘要] 目的 探讨新型镁合金对金黄色葡萄球菌生物学特性的影响。 方法 实验分为实验组(新型镁合金)及对照组(不含新型镁合金),各设3个复孔,分别进行金黄色葡萄球菌增殖实验、金黄色葡萄球菌血浆凝固酶实验、金黄色葡萄球菌溶血素实验、抗生素抑菌实验,最后进行统计学分析。 结果 细菌增殖实验结果显示,在同一时间点不同浓度实验组OD值比对照组明显更低,差异有统计学意义(P < 0.05);在不同时间点相同浓度实验组与对照组比较,OD值明显更低(P < 0.05);随着培养时间延长,相同浓度实验组与对照组OD值之差逐渐上升(P < 0.05)。金黄色葡萄球菌血浆凝固酶实验结果显示,与对照组比较,实验组凝集颗粒较小,且随着培养时间延长,凝集颗粒逐渐变小。金黄色葡萄球菌溶血素实验结果显示,与对照组比较,实验组β溶血环较小,且随着培养时间延长,β溶血环逐渐减小,而且培养7 d后,β溶血环消失。抗生素抑菌环实验结果显示,与对照组比较,实验组所有抗生素在第1、3、5、7天抑菌环直径较大,差异有统计学意义(P < 0.05)。 结论 镁合金具有抑制金黄色葡萄球菌增殖的能力,同时,对其血浆凝固酶、溶血素及抗生素抑菌特性也有影响。
英文摘要:
      [Abstract] Objective To explore the effect of a new magnesium alloy on the biological characteristics of Staphylococcus aureus. Methods There were two groups, an experimental group (with new magnesium alloy) and a control group (without new magnesium alloy) in the experiment, each with 3 replicate wells. Staphylococcus aureus proliferation experiment, Staphylococcus aureus plasma coagulase experiment,Staphylococcus aureus hemolysin experiment, and antibiotic antibacterial ring experiment were conducted respectively, and statistical analysis was performed after the experiments. Results The results of bacterial proliferation experiments showed that at the same time point, the OD values of the experimental group with different concentrations were significantly lower than those of the control group, with statistically significant differences (P < 0.05). At different time points, the OD values of the experimental group at the same concentration were significantly lower than those of the control group (P < 0.05). As the cultivation time prolonged, the difference in OD values between the experimental group and the control group at the same concentration gradually increased (P < 0.05). The results of the Staphylococcus aureus plasma coagulase experiment showed that compared with the control group, the experimental group had smaller agglutination particles, and as the cultivation time prolonged, the agglutination particles gradually became smaller. The hemolysin test results of Staphylococcus aureus showed that compared with the control group, the β-hemolytic rings in the experimental group were relatively small and decreased with culture time, and after 7 days of cultivation, the β-hemolytic rings disappeared. The results of the antibiotic antibacterial ring experiment showed that compared with the control group, all antibiotics in the experimental group had larger inhibition ring diameters at days 1, 3, 5, and 7, with statistically significant differences (P < 0.05). Conclusion Magnesium alloy has the ability to inhibit the proliferation of Staphylococcus aureus. At the same time, it also has impacts on its plasma coagulase, hemolysin, and antibiotic antibacterial properties.
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