| 陈静，金灿灿，周皓鹏，张茜蕙，梅辉.不同病情乙型肝炎患者HBV-DNA定量、两对半检测结果差异[J].中国医药科学,2024,14(5):161-164 基金项目: |
| 不同病情乙型肝炎患者HBV-DNA定量、两对半检测结果差异 |
| Differences in HBV-DNA quantification and serologic test results among patients with different conditions of hepatitis B |
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| DOI： |
| 中文关键词: 乙型肝炎；乙肝两对半；HBV-DNA定量；相关性分析 |
| 英文关键词:Hepatitis B; Hepatitis B serologic test; HBV-DNA quantification; Correlation analysis |
| 作者 | 单位 | | 陈静，金灿灿，周皓鹏，张茜蕙，梅辉 | 江苏省泰兴市人民医院检验科，江苏泰州 225400 |
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| 中文摘要: |
| [摘要] 目的 分析乙型肝炎患者乙型肝炎病毒（HBV）-DNA定量检测与两对半检测结果的相关性，并观察不同病情HBV-DNA阳性率和两对半检测结果差异。 方法 选取江苏省泰兴市人民医院2021年4月至2023年4月收治的375例乙型肝炎患者病例为研究资料。比较不同乙肝两对半检测[乙肝表面抗原（HBsAg）、乙肝表面抗体（HBsAb）、乙肝e抗原（HBeAg）、乙肝e抗体（HBeAb）、乙肝核心抗体（HBcAb）]结果患者HBV-DNA定量检测结果差异，将患者根据HBV-DNA定量检测结果分为阳性组和阴性组，比较乙肝两对半结果差异，使用Pearson相关性分析；将患者根据疾病类型分为肝炎组、肝硬化组和肝癌组，比较三组患者乙肝两对半和HBV-DNA定量检测结果差异。 结果 不同乙肝两对半类型患者HBV-DNA阳性率比较，差异有统计学意义（P < 0.05）；HBV-DNA阳性组患者HBsAg、HBeAg水平高于HBV-DNA阴性组，HBsAb、HBeAb、HBcAb水平低于HBV-DNA阴性组，差异有统计学意义（P < 0.05）；HBsAg、HBeAg水平与HBV-DNA呈正相关（P < 0.05），HBsAb、HBeAb、HBcAb水平与HBV-DNA呈负相关（P < 0.05）；不同疾病类型患者乙肝两对半类型HBV-DNA阳性率比较，差异有统计学意义（P < 0.05），不同疾病类型患者HBV-DNA定量检测结果比较，差异有统计学意义（P < 0.05）。 结论 乙型肝炎患者HBV-DNA定量检测与两对半检测结果有相关性，不同乙肝两对半类型间及不同疾病类型间HBV-DNA均有差异，HBV-DNA定量检测联合两对半检测可较好地反映病毒复制和疾病进展情况，为临床治疗提供指导。 |
| 英文摘要: |
| [Abstract] Objective To analyze the correlation between the HBV-DNA quantification and serologic test results n patients with hepatitis B, and to observe the differences in the positive rates of hepatitis B virus (HBV)-DNA and the results of serologic tests in different diseases. Methods A total of 375 hepatitis B patients admitted to the Taixing People’s Hospital, Jiangsu Province from April 2021 to April 2023 were selected as the research data. The difference of HBA-DNA quantification test results of patients with different hepatitis B serologic test results (hepatitis B surface antigen [HBsAg], hepatitis B surface antibody [HBsAb], hepatitis B e antigen [HBeAg], hepatitis B e antibody [HBeAb], hepatitis B core antibody [HBcAb]) was compared, and the patients were divided into a positive group and a negative group according to the HBV-DNA quantification test results. The difference of the hepatitis B serologic test was compared, and Pearson correlation analysis was used; The patients were divided into a hepatitis group, a cirrhosis group, and a liver cancer group according to the disease type, and the differences of hepatitis B serologic test types and the HBV-DNA quantification test results among the three groups were compared. Results The positive rate of HBV-DNA in patients with different hepatitis B serologic test models was compared, with statistically significant difference (P < 0.05). The levels of HBsAg and HBeAg of patients in the HBV-DNA positive group were higher than those of patients in the HBV-DNA negative group, while the levels of HBsAb, HBeAb, and HBcAb were lower than those in the HBV-DNA negative group, with statistically significant differences (P < 0.05). The levels of HBsAg and HBeAg were positively correlated with HBV-DNA (P < 0.05), while the levels of HBsAb, HBeAb, and HBcAb were negatively correlated with HBV-DNA (P < 0.05). The positive rate of types of hepatitis B serologic test in patients with different disease types were compared, with statistically significant difference (P < 0.05), and the quantitative detection results of HBV-DNA in patients with different disease types was compared, with statistically significant difference (P < 0.05). Conclusion The HBV-DNA quantification test in patients with hepatitis B is correlated with the serologic test results. There are differences in HBV-DNA between different hepatitis B serologic test models and between different diseases. The combination of HBV-DNA quantification test and serologic test can better reflect the situation of virus replication and disease progress and guide clinical treatment. |
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