金东升.健脾补肺汤对小儿咳嗽变异性哮喘炎症因子、免疫功能的影响[J].中国医药科学,2023,(20):66-69 基金项目: |
健脾补肺汤对小儿咳嗽变异性哮喘炎症因子、免疫功能的影响 |
Impacts of Jianpi Bufei Decoction on inflammatory factors and immune function in children with cough variant asthma |
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DOI: |
中文关键词: 健脾补肺汤;小儿;咳嗽变异性哮喘;炎性因子;免疫功能 |
英文关键词:Jianpi Bufei Decoction; Children; Cough variant asthma; Inflammatory factors; Immune function |
作者 | 单位 | 金东升 | 浙江省东阳市妇幼保健院儿科门诊,浙江东阳 322100 |
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中文摘要: |
[摘要]目的 探究健脾补肺汤对小儿咳嗽变异性哮喘炎症因子以及免疫功能的影响。方法 前瞻性选取2022年1—5月东阳市妇幼保健院中医儿科收治的105例咳嗽变异性哮喘患儿为研究对象,根据随机数表法分为汤药组(n=54)和对照组(n=51)。对照组给予常规药物治疗,汤药组在对照组的治疗基础上加服健脾补肺汤,比较两组的临床疗效、治疗前后的中医证候评分、哮喘控制测试(ACT)评分、炎性因子水平、免疫功能及不良反应。结果 汤药组总有效率高于对照组,差异有统计学意义(P < 0.05)。治疗后两组患者中医证候评分、嗜酸性粒细胞(EOS)比率、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、免疫球蛋白(IgE)均低于治疗前,且汤药组中医证候评分、EOS比率、IL-6、TNF-α、IgE低于对照组,差异有统计学意义(P < 0.05);治疗后两组患者ACT评分、CD3+、CD4+均高于治疗前,且汤药组ACT评分、CD3+、CD4+高于对照组,差异有统计学意义(P < 0.05)。两组不良反应总发生率比较,差异无统计学意义(P > 0.05)。结论 咳嗽变异性哮喘患者加服健脾补肺汤可提高患者临床治疗效果,减轻咳嗽症状,降低炎性水平及过敏反应,提高患儿免疫功能,且用药安全性高,具有较好的推广价值。 |
英文摘要: |
[Abstract] Objective To investigate the impacts of Jianpi Bufei decoction on inflammatory factors and immune function in children with cough variant asthma. Methods A total of 105 children with cough variant asthma admitted to and treated in the Department of Pediatrics in Traditional Chinese Medicine (TCM) in the Dongyang Maternal and Child Health Care Hospital from January to May 2022 were selected prospectively. They were divided into the decoction group (n=54) and the control group (n=51) according to the random number table method. The control group was treated with conventional medication, while the decoction group was treated with Jianpi Bufei decoction on the medication basis of the control group. The clinical efficacy, TCM syndrome score, asthma control test (ACT) score, inflammatory factor level, immune function and adverse reactions before and after treatment of the two groups were compared. Results The TCM evidence score, eosinophil (EOS) ratio, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and immunoglobulin (IgE) of patients in the two groups were lower than that before treatment, and the TCM evidence score, EOS ratio, IL-6, TNF- α, and IgE were lower than those in the control group, with statistically significant differences (P < 0.05). ACT scores, CD3+, and CD4+ were higher than those before treatment in both groups, and ACT scores, CD3+, and CD4+ were higher in the tonic group than those in the control group, with statistically significant differences (P < 0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P > 0.05). Conclusion Combining with Jianpi Bufei decoction in patients with cough variant asthma can improve the clinical therapeutic efficacy, relieve cough symptoms, reduce inflammatory level and allergic reaction, and improve affected children’s immune function, with high medication safety and better promotion value. |
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