| 秦汉1，李玲2，张竞飞2，刘代利1，石菲2，孙笑洋1，王智2，蔡圳2▲.小檗碱促进骨再生的研究进展[J].中国医药科学,2023,(19):45-49 基金项目:山东省中医药科技项目（2021M024） |
| 小檗碱促进骨再生的研究进展 |
| Research progress of berberine in promoting osteanagenesis |
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| DOI： |
| 中文关键词: 小檗碱；成骨细胞；破骨细胞；骨再生 |
| 英文关键词:Berberine; Osteoblast; Osteoclast; Osteanagenesis |
| 作者 | 单位 | | 秦汉1，李玲2，张竞飞2，刘代利1，石菲2，孙笑洋1，王智2，蔡圳2▲ | 1.滨州医学院口腔医学院，山东烟台 264000；2.山东省临沂市人民医院口腔科，山东临沂 276000 |
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| 中文摘要: |
| [摘要] 小檗碱作为一种从传统中药中提取的天然异喹啉生物碱，具有预防骨质疏松、抗炎、降血糖等多种生物功效且副作用小。小檗碱不仅可以通过激活经典成骨信号通路Wnt/β-catenin和丝裂原活化蛋白激酶（MAPK）等有效促进干细胞成骨分化，还可以通过干扰核因子κB（NF-κB）受体活化因子配体（RANKL）与NF-κB受体活化因子（RANK）之间的结合，进而影响下游的信号通路如MAPK、NF-κB等抑制破骨细胞的分化，促进骨再生。本文对小檗碱促进骨再生的作用机制进行综述，旨在为骨再生的研究提供新的思路。 |
| 英文摘要: |
| [Abstract] Berberine, as a natural isoquinoline alkaloid extracted from traditional Chinese medicine, has many biological effects, such as preventing osteoporosis, anti-inflammatory and decreasing blood sugar with few side effects. Berberine can not only effectively promote the osteogenic differentiation of stem cells by activating classical osteogenic signaling pathways Wnt/β-catenin and mitogen-activated protein kinase(MAPK), but also interfere with the binding between receptor activator of NF-κB ligand (RANKL), and receptor activator of NF-κB (RANK), thus affecting downstream signaling pathways such as MAPK and nuclear factor kappa-B (NF-κB), so as to inhibit the differentiation of osteoclasts and promote osteanagenesis. In this paper, the mechanism of berberine promoting osteanagenesis is reviewed, aiming at providing new ideas for the study of osteanagenesis. |
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