| 罗芹，赵昀辉.宫腔镜电切术后联合醋酸甲地孕酮对早期子宫内膜癌患者VEGF、YKL-40的影响[J].中国医药科学,2023,(14):102-105 基金项目: |
| 宫腔镜电切术后联合醋酸甲地孕酮对早期子宫内膜癌患者VEGF、YKL-40的影响 |
| Impacts of hysteroscopic electrotomy combined with megestrol acetate on VEGF and YKL-40 in patients with early endometrial carcinoma |
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| DOI： |
| 中文关键词: 醋酸甲地孕酮；宫腔镜电切术；早期子宫内膜癌；糖类抗原125；血管内皮生长因子 |
| 英文关键词:Megestrol acetate; Hysteroscopic electrotomy; Early endometrial carcinoma; Carbohydrate antigen 125; Vascular endothelial growth factor |
| 作者 | 单位 | | 罗芹，赵昀辉 | 云南省红河州第三人民医院妇科肿瘤科，云南红河 661000 |
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| 中文摘要: |
| [摘要] 目的 研究早期子宫内膜癌（EC）患者应用醋酸甲地孕酮联合宫腔镜电切术治疗的效果。 方法 选取2019年1月至2022年1月红河州第三人民医院收治的80例早期EC患者，按随机数表法分为对照组（40例）和研究组（40例），对照组行宫腔镜电切术治疗，研究组行醋酸甲地孕酮联合宫腔镜电切术治疗，比较两组疗效、生活质量、血清肿瘤标志物。 结果 研究组治疗有效率为87.50%，高于对照组的62.50%，差异有统计学意义（P < 0.05）；研究组治疗后糖类抗原125（CA125）、甲壳质酶蛋白-40（YKL-40）水平低于对照组，差异有统计学意义（P < 0.05）；研究组治疗后血管内皮生长因子（VEGF）、基质金属蛋白酶-9（MMP-9）及肿瘤坏死因子-α（TNF-α）水平低于对照组，差异有统计学意义（P < 0.05）；研究组治疗后QLQ-C30各项评分高于对照组，差异有统计学意义（P < 0.05）。 结论 醋酸甲地孕酮联合宫腔镜电切术用于早期EC患者治疗，可促进疗效提高，下调肿瘤标志物表达水平，有利于提高患者生活质量。 |
| 英文摘要: |
| [Abstract] Objective To study the effect of megestrol acetate combined with hysteroscopic electrotomy in the treatment of patients with early endometrial carcinoma (EC). Methods A total of 80 patients with early EC admitted to and treated in Honghe Prefecture Third People’s Hospital from January 2019 to January 2022 were selected, and they were divided into the control group (n=40) and the study group (n=40) according to the random number table method. The control group was treated with hysteroscopic electrotomy, while the study group was treated with megestrol acetate combined with hysteroscopic electrotomy. The therapeutic efficacy, quality of life (QoL) and serum tumor markers were compared between the two groups. Results The treatment efficacy rate in the study group was 87.50%, higher than 62.50% in the control group, with statistically significant difference (P < 0.05); After treatment, the levels of carbohydrate antigen 125 (CA125) and chitinase protein 40 (YKL-40) in the study group were lower than those in the control group, with statistically significant differences (P < 0.05); After treatment, the levels of vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9) and tumor necrosis factor-α (TNF-α) in the study group were lower than those in the control group, with statistically significant differences (P < 0.05). After treatment, all QLQ-C30 scores in the study group were higher than those in the control group, with statistically significant differences (P < 0.05). Conclusion Megestrol acetate combined with hysteroscopic electrotomy can improve the therapeutic efficacy, down-regulate the expression level of tumor markers, and improve the QoL of patients with early EC. |
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