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曾灏,翚缨,张林芝.血清AFP、AFP-L3%、CA199、PIVKA-Ⅱ联合GP73检测对肝细胞癌的诊断价值[J].中国医药科学,2023,(1):149-152        基金项目:[基金项目] 广西壮族自治区卫生健康委员会科研课题(Z20190320)
血清AFP、AFP-L3%、CA199、PIVKA-Ⅱ联合GP73检测对肝细胞癌的诊断价值
Diagnostic value of combined detection of serum AFP, AFP-L3%, CA199, PIVKA-Ⅱ and GP73 in hepatocellular carcinoma
  
DOI:
中文关键词:  糖类抗原-199;甲胎蛋白;肝细胞癌;高尔基体蛋白73
英文关键词:Carbohydrate antigen 199; Alpha fetoprotein; Hepatocellular carcinoma; Golgi protein 73
作者单位
曾灏,翚缨,张林芝 广西壮族自治区贵港市人民医院检验科,广西贵港 537100 
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中文摘要:
      [摘要] 目的 探讨联合检测血清甲胎蛋白(AFP)、甲胎蛋白异质体-L3比率(AFP-L3%)、糖类抗原-199(CA199)、异常凝血酶原(PIVKA-Ⅱ)、高尔基体蛋白73(GP73)在肝细胞癌诊断中的价值。 方法 选取2019年1月至2022年1月贵港市人民医院收治的肝细胞癌患者共40例作为恶性组,同期确诊良性肝病患者40例作为良性组,同期健康体检者共40例作为健康组。三组均检测血清AFP、AFP-L3%、CA199、PIVKA-Ⅱ、GP73。对三组检测结果进行评析,并讨论单独检测与联合检测的诊断结果。 结果 恶性组AFP、AFP-L3%、CA199、PIVKA-Ⅱ、GP73检测结果依次为(189.73±22.05)ng/ml、(16.84±2.44)%、(107.27±15.26)U/ml、(20 381.67±3512.21)mAu/ml、(177.54±22.62)ng/ml,高于良性组、健康组,差异有统计学意义(P < 0.05);Ⅲ~Ⅳ期患者的AFP、AFP-L3%、CA199、PIVKA-Ⅱ、GP73水平均高于Ⅰ~Ⅱ期患者,差异有统计学意义(P < 0.05);联合检测的敏感度、特异度、准确度依次为95.00%、92.50%、93.33%,均高于单独检测,差异有统计学意义(P < 0.05)。 结论 肝细胞癌诊断中,联合血清AFP、AFP-L3%、CA199、PIVKA-Ⅱ、GP73检测具有较高的敏感度、特异度,可提高肝细胞癌诊断准确度,具有较高的诊断价值,值得推广。
英文摘要:
      [Abstract] Objective To explore the value of combined detection of serum alpha fetoprotein (AFP), alpha fetoprotein hetero-L3 ratio (AFP-L3%), carbohydrate antigen 199 (CA199), protein induced by vitamin k absence or antagonist-Ⅱ (PIVKA-Ⅱ), and golgi protein 73 (GP73) in the diagnosis of hepatocellular carcinoma. Methods A total of 40 patients with hepatocellular carcinoma treated in Guigang City People’s Hospital from January 2019 to January 2022 were selected as the malignant group. A total of 40 patients concurrently diagnosed with benign liver disease were selected as the benign group. A total of 40 healthy individuals undergoing physical examination in the same period were selected as the healthy group. Serum AFP, AFP-L3%, CA199, PIVKA-Ⅱ and GP73 were detected in the three groups. The detection results of the three groups were evaluated, and the diagnostic results of single detection and combined detection were discussed. Results The detection results of AFP, AFP-L3%, CA199, PIVKA-Ⅱ and GP73 in the malignant group ([189.73±22.05] ng/ml, [16.84±2.44]%, [107.27±15.26] U/ml, [20 381.67±3512.21] mAu/ml and [177.54±22.62] ng/ml) were higher than those in the benign group and the healthy group, with statistically significant differences (P < 0.05). The levels of AFP, AFP-L3%, CA199, PIVKA-Ⅱ and GP73 in stage Ⅲ-Ⅳ patients were significantly higher than those in stage Ⅰ-Ⅱ patients, with statistically significant differences (P < 0.05). The sensitivity, specificity and accuracy of the combined detection were 95.00%, 92.50% and 93.33% respectively, which were higher than those of the single detection, and the differences were statistically significant (P < 0.05). Conclusion In the diagnosis of hepatocellular carcinoma, the combined detection of serum AFP, AFP-L3%, CA199, PIVKA-Ⅱ and GP73 has high sensitivity and specificity, can improve the diagnostic accuracy of hepatocellular carcinoma, has high diagnostic value, and is worth popularizing.
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