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刘英杰.参附养心汤联合比索洛尔对阳虚水泛型老年慢性心力衰竭患者心功能及炎症因子的影响[J].中国医药科学,2023,(1):107-110        基金项目:
参附养心汤联合比索洛尔对阳虚水泛型老年慢性心力衰竭患者心功能及炎症因子的影响
Effect of Shenfu Yangxin Decoction combined with bisoprolol on cardiac function and inflammatory factors in elderly patients with chronic heart failure with yang deficiency and water accumulation syndrome
  
DOI:
中文关键词:  慢性心力衰竭;阳虚水泛型;参附养心汤;比索洛尔;心功能;炎症因子
英文关键词:Chronic heart failure; Yang deficiency and water accumulation syndrome; Shenfu Yangxin Decoction; Bisoprolol; Cardiac function; Inflammatory factor
作者单位
刘英杰 北京王府中西医结合医院心血管内科,北京 102209 
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中文摘要:
      [摘要] 目的 探究参附养心汤联合比索洛尔对阳虚水泛型老年慢性心力衰竭(CHF)患者心功能及炎症因子的影响。方法 选择2020年5月至2022年3月北京王府中西医结合医院收治的老年阳虚水泛型CHF患者86例,按随机数表法分为两组,每组各43例。对照组口服比索洛尔,观察组加服参附养心汤,均持续治疗8周。比较两组临床疗效、中医证候积分、心功能、炎症因子水平、不良反应。 结果 观察组治疗总有效率(95.35%)高于对照组(79.07%),差异有统计学意义(P < 0.05);治疗前,两组中医证候积分、心功能、炎症因子水平比较,差异无统计学意义(P > 0.05);治疗后,观察组中医证候积分及左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)均低于对照组,左心室射血分数(LVEF)较对照组高,肿瘤坏死因子(TNF-α)、C反应蛋白(CRP)水平均低于对照组,差异有统计学意义(P < 0.05);两组均未发生严重不良反应。 结论 参附养心汤联合比索洛尔治疗阳虚水泛型老年CHF疗效确切,能够减轻炎症反应及中医证候,改善患者心功能,且安全性高。
英文摘要:
      [Abstract] Objective To explore the effect of Shenfu Yangxin Decoction combined with bisoprolol on cardiac function and inflammatory factors in elderly patients with chronic heart failure (CHF) with yang deficiency and water accumulation syndrome. Methods A total of 86 elderly CHF patients with yang deficiency and water accumulation syndrome who were admitted to Beijing Royal Integrative Medicine Hospital from May 2020 to March 2022 were selected and randomly divided into two groups according to the random number table method, with 43 patients in each group. The control group was orally administrated with bisoprolol, while the observation group was administrated with Shenfu Yangxin Decoction on the basis of oral bisoprolol. All the patients received continuous treatment for 8 weeks. The clinical efficacy, TCM syndrome scores, cardiac function, levels of inflammatory factors and adverse reactions were compared between the two groups. Results The total effective rate of the observation group (95.35%) was higher than that of the control group (79.07%), with statistically significant difference (P < 0.05). Before treatment, there were no significant differences in TCM syndrome scores, cardiac function and levels of inflammatory factors between the two groups (P > 0.05). After treatment, the TCM syndrome score, left ventricular end systolic diameter (LVESD) and left ventricular end diastolic diameter (LVEDD) of the observation group were lower than those of the control group, the left ventricular ejection fraction (LVEF) of the observation group was higher than that of the control group, and the levels of tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) of the observation group were lower than those of the control group, with statistically significant differences (P < 0.05). No serious adverse reactions were observed in the two groups. Conclusion Shenfu Yangxin Decoction combined with bisoprolol is effective for the treatment of elderly CHF patients with yang deficiency and water accumulation syndrome, and it can reduce the inflammatory response and TCM syndrome and improve the cardiac function of patients, with high safety.
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关键词: 中国医药科学 中国医学 中国医学科学 中华医学 医学杂志 临床医学杂志 医学期刊 中国预防医学 中华预防医学 预防医学杂志 中国药学 药学杂志
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