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王虎1,徐良成2,张艳1▲.胺碘酮与普罗帕酮在阵发性室上性心动过速患者院前急救中的效果[J].中国医药科学,2023,(1):12-15        基金项目:[基金项目]江苏省连云港市卫生健康委员会科研计划项目(LHCM2018-32)
胺碘酮与普罗帕酮在阵发性室上性心动过速患者院前急救中的效果
The efficacy of amiodarone and propafenone in pre-hospital emergency care of patients with paroxysmal supraventricular tachycardia
  
DOI:
中文关键词:  胺碘酮;普罗帕酮;室上性心动过速;急救
英文关键词:Amiodarone; Propafenone; Supraventricular tachycardia; Emergency care
作者单位
王虎1,徐良成2,张艳1▲ 1.江苏省连云港市急救中心,江苏连云港 222000;2.江苏省连云港市第一人民医院心内科,江苏连云港 222000 
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中文摘要:
      [摘要] 目的 分析胺碘酮与普罗帕酮在阵发性室上性心动过速患者院前急救中的效果。 方法 选择2019年6月至2021年6月连云港市急救中心收治的院前急救阵发性室上性心动过速患者100例作为研究对象,采用随机数表法分为观察组(n=50)和对照组(n=50)。院前急救,对照组患者采用胺碘酮治疗,观察组实施普罗帕酮治疗。比较两组心动过速转归率、血细胞指标、急救效果。 结果 急救后,两组患者血细胞比容、血浆比黏度、纤维蛋白原、红细胞沉降率均低于急救前,差异有统计学意义(P < 0.05),急救后,两组血细胞参数比较,差异无统计学意义(P > 0.05);观察组患者的转归率高于对照组,差异有统计学意义(P < 0.05);观察组患者药物起效、复律时间低于对照组,差异有统计学意义(P < 0.05);不良反应发生率高于对照组,差异有统计学意义(P < 0.05)。 结论 院前急救,选择普罗帕酮、胺碘酮转复阵发性室上性心动过速均具有较好的疗效,各有优劣。普罗帕酮起效快,安全性相对较低,胺碘酮起效慢,安全性更高,适用范围广,临床上需要根据患者情况合理选择治疗药物。
英文摘要:
      [Abstract] Objective To analyze the efficacy of amiodarone and propafenone in pre-hospital emergency care of patients with paroxysmal supraventricular tachycardia (PSVT). Methods A total of 100 patients with PSVT admitted to and treated in Lianyungang Emergency Center from June 2019 to June 2021 were selected as the research subjects, and they were divided into the observation group (n=50) and the control group (n=50) according to the random number table method. Patients were treated with pre-hospital emergency care. The control group was treated with amiodarone, while the observation group was treated with propafenone.The tachycardia rate, blood cell index and first aid effect were compared between the two groups. Results After treatment, the hematocrit (HCT), ratio of viscosity, fibrinogen and erythrocyte sedimentation rate (ESR) of patients in the two groups were all lower than those before treatment, with statistically significant differences (P < 0.05). There was no statistically significant difference in blood cell parameters between the two groups after emergency care (P > 0.05). The outcome rate of patients in the observation group was higher than that in the control group, with statistically significant difference (P < 0.05). The onset time and cardioversion time of drugs in patients in the observation group were shorter than those in the control group, with statistically significant differences (P < 0.05). The incidence of adverse reactions (ADRs) of the observation group was higher than that of the control group, with statistically significant difference (P < 0.05). Conclusion For the pre-hospital emergency care, the choices of propafenone and amiodarone are both effective in the conversion of PSVT, and each has its own advantages and disadvantages. Propafenone has a fast efficacy but a relatively lower safety, while amiodarone has a slow efficacy but a relatively higher safety and a wide application range. Therefore, it is necessary to choose a reasonable treatment drug according to the patient’s condition clinically.
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关键词: 中国医药科学 中国医学 中国医学科学 中华医学 医学杂志 临床医学杂志 医学期刊 中国预防医学 中华预防医学 预防医学杂志 中国药学 药学杂志
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