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樊春华,胡瑾君,陈文剑.加味香砂六君子汤配合穴位贴敷治疗慢性萎缩性胃炎的效果及对T淋巴细胞亚群、COX-2的影响[J].中国医药科学,2023,(1):8-11        基金项目:[基金项目]广东省广州市中医药和中西医结合科技项目(20212A010003)
加味香砂六君子汤配合穴位贴敷治疗慢性萎缩性胃炎的效果及对T淋巴细胞亚群、COX-2的影响
Effect of Modified Xiangsha Liujunzi Decoction combined with acupoint application on chronic atrophic gastritis and its influence on T lymphocyte subsets and COX-2
  
DOI:
中文关键词:  加味香砂六君子汤;穴位贴敷;慢性萎缩性胃炎;临床疗效;T淋巴细胞亚群;环氧化酶-2
英文关键词:Modified Xiangsha Liujunzi Decoction; Acupoint application; Chronic atrophic gastritis; Clinical efficacy; T lymphocyte subsets; Cyclooxygenase-2
作者单位
樊春华,胡瑾君,陈文剑 广州医科大学附属中医医院脾胃病科, 广东广州 510000 
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中文摘要:
      [摘要] 目的 研究加味香砂六君子汤配合穴位贴敷治疗慢性萎缩性胃炎的临床效果。 方法 选取2020年1月至2021年4月广州医科大学附属中医医院收治的慢性萎缩性胃炎患者90例,按随机数表法分两组,每组各45例。对照组口服胃复春片治疗,观察组采用加味香砂六君子汤配合穴位贴敷治疗,比较两组在临床总有效率、临床症状积分、T淋巴细胞亚群、COX-2表达方面的异同。 结果 观察组和对照组的总有效率比较,观察组大于对照组,差异有统计学意义(P < 0.05);治疗前,观察组和对照组的临床症状积分比较,差异无统计学意义(P > 0.05),治疗后两组的临床症状积分小于治疗前,差异有统计学意义(P < 0.05),治疗后,观察组的临床症状积分小于对照组,差异有统计学意义(P < 0.05);治疗前,观察组与对照组的T淋巴细胞亚群指标比较,差异无统计学意义(P > 0.05),治疗后观察组的分化簇3(CD3+)、分化簇4(CD4+)、CD4+/CD8+均明显大于对照组,分化簇8(CD8+)明显小于对照组,差异有统计学意义(P < 0.05);两组治疗后的COX-2表达均显著低于治疗前,差异有统计学意义(P < 0.05),观察组治疗后的COX-2表达显著低于对照组,差异有统计学意义(P < 0.05)。 结论 采用加味香砂六君子汤配合穴位贴敷治疗慢性萎缩性胃炎的总体疗效显著。
英文摘要:
      [Abstract] Objective To study the clinical efficacy of Modified Xiangsha Liujunzi Decoction combined with acupoint application on chronic atrophic gastritis. Methods A total of 90 patients with chronic atrophic gastritis admitted to the Affiliated Traditional Chinese Medicine Hospital of Guangzhou Medical University from January 2020 to April 2021 were selected and randomly divided into two groups by the random number table method, with 45 patients in each group. The control group was treated with oral Weifuchun Pian, while the observation group was treated with Modified Xiangsha Liujunzi Decoction combined with acupoint application. The differences and similarities in clinical total effective rates, clinical symptom scores, T lymphocyte subsets and COX-2 expressions between the two groups were compared. Results The total effective rate of the observation group was higher than that of the control group, with statistical significance differences (P < 0.05). Before treatment, there was no significant difference between the clinical symptom scores of the observation group and the control group (P > 0.05). The clinical symptom scores of the two groups after treatment were lower than those before treatment, with statistically significant differences (P < 0.05). After treatment, the clinical symptom scores of the observation group were lower than those of the control group, with statistically significant differences (P < 0.05). Before treatment, there was no significant difference in T lymphocyte subsets between the observation group and the control group (P > 0.05). After treatment, the levels of cluster of differentiation 3 (CD3+), cluster of differentiation 4 (CD4+) and CD4+/CD8+ of the observation group were significantly higher than those of the control group, and the level of cluster of differentiation 8 (CD8+) of the observation group was significantly lower than that of the control group, with statistically significant differences (P < 0.05). The expression of COX-2 in the two groups after treatment was significantly lower than that before treatment (P < 0.05), and the expression of COX-2 in the observation group was significantly lower than that in the control group, with statistically significant differences (P < 0.05). Conclusion The overall efficacy of Modified Xiangsha Liujunzi Decoction combined with acupoint application on chronic atrophic gastritis is significant.
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