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成艳兰.普拉洛芬滴眼液联合玻璃酸钠滴眼液对干眼症患者的影响[J].中国医药科学,2022,(20):177-180        基金项目:
普拉洛芬滴眼液联合玻璃酸钠滴眼液对干眼症患者的影响
Effect of pranoprofen eye drops combined with sodium hyaluronate eye drops on patients with dry eye
  
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中文关键词:  
英文关键词:Pranoprofen eye drops; Sodium hyaluronate eye drops; Dry eye; Tear secretion test; Tear break-up time; Corneal fluorescein staining score
作者单位
成艳兰 湖北省钟祥市人民医院眼科,湖北钟祥 431900 
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中文摘要:
      [摘要] 目的 探讨普拉洛芬滴眼液联合玻璃酸钠滴眼液对干眼症患者泪液分泌试验和泪膜破裂时间(BUT)的影响。 方法 选取2019年2月至2021年2月在钟祥市人民医院确诊的72例干眼症患者,随机分为观察组和对照组,每组各36例。对照组给予玻璃酸钠滴眼液治疗,观察组在对照组基础上联合普拉洛芬滴眼液治疗,均持续治疗1个月。分别于治疗前后比较两组患者临床症状评分、Schirmer试纸长度、BUT、角膜荧光素染色评分,比较两组治疗期间的不良反应发生率。 结果 治疗后,观察组患者的体征和自觉症状评分低于对照组,差异有统计学意义(P < 0.05);治疗后,观察组患者的Schirmer试纸长度和BUT长于对照组,差异有统计学意义(P < 0.05);治疗后,观察组患者的角膜荧光素染色评分低于对照组,差异有统计学意义 (P < 0.05)。观察组患者的用药不良反应总发生率为8.33%,与对照组患者的11.11%比较,差异无统计学意义(P > 0.05)。 结论 普拉洛芬滴眼液结合玻璃酸钠滴眼液可以明显提高干眼症患者的临床疗效,改善临床症状,延长泪膜破裂时间。
英文摘要:
      [Abstract] Objective To investigate the effect of pranoprofen eye drops combined with sodium hyaluronate eye drops on tear secretion test and tear break-up time (BUT) in patients with dry eye. Methods A total of 72 patients with dry eye diagnosed in Zhongxiang People’s Hospital from February 2019 to February 2021 were randomly divided into the observation group and the control group, with 36 cases in each group. The control group received sodium hyaluronate eye drops, while the observation group received pranoprofen eye drops on the basis of the treatment of the control group, both of which lasted for one month. The clinical symptom score, Schirmer strip length, BUT and corneal fluorescein staining score before and after treatment between the two groups were compared, and the incidence of adverse reactions during treatment between the two groups was compared. Results After treatment, the scores of physical signs and subjective symptoms in the observation group were lower than those in the control group, with statistically significant differences (P < 0.05). After treatment, the Schirmer strip length and BUT of the observation group were longer than those of the control group, with statistically significant differences (P < 0.05). After treatment, the corneal fluorescein staining score of the observation group was lower than that of the control group, with statistically significant difference (P < 0.05). The total incidence of adverse drug reactions in the observation group was 8.33%, which had no significant difference compared with 11.11% in the control group(P > 0.05). Conclusion Pranoprofen eye drops combined with sodium hyaluronate eye drops can obviously improve the clinical efficacy in patients with dry eye, improve clinical symptoms and prolong tear break-up time.
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