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邱辉,徐亚非,伍美艺,刘永明,李冠军,谢健良.负压封闭引流、臭氧生理盐水冲洗联合载敏感抗生素硫酸钙治疗慢性骨髓炎的效果[J].中国医药科学,2022,(20):158-160        基金项目:广东省佛山市卫生健康局医学科研课题(20210073)
负压封闭引流、臭氧生理盐水冲洗联合载敏感抗生素硫酸钙治疗慢性骨髓炎的效果
Curative effect of vacuum sealing drainage and ozone saline flushing combined with sensitive antibiotic-loaded calcium sulfate in the treatment of chronic osteomyelitis
  
DOI:
中文关键词:  慢性骨髓炎;硫酸钙;负压封闭引流;敏感抗生素;炎症因子
英文关键词:Chronic osteomyelitis; Calcium sulfate; Vacuum sealing drainage; Sensitive antibiotic; Inflammatory factor
作者单位
邱辉,徐亚非,伍美艺,刘永明,李冠军,谢健良 南方医科大学第七附属医院骨科,广东佛山 528244 
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中文摘要:
      [摘要] 目的 探讨负压封闭引流、臭氧生理盐水冲洗联合载敏感抗生素硫酸钙治疗慢性骨髓炎的疗效。 方法 选择2020年1月至2021年8月南方医科大学第七附属医院收治的慢性骨髓炎患者作为研究对象,共45例,按照随机数表法分为两组,对照组22例采取载万古霉素硫酸钙治疗,观察组23例采取负压封闭引流、臭氧生理盐水冲洗联合载敏感抗生素硫酸钙治疗,比较治疗效果、细菌清除率、骨髓炎复发率,测定治疗前后患者的C反应蛋白(CRP)、肿瘤坏死因子(TNF-α)、红细胞沉降率(ESR)。 结果 观察组治疗总有效率(95.65%)高于对照组(72.73%),细菌清除率(95.65%)高于对照组(68.18%),差异有统计学意义(P < 0.05)。观察组术后6个月复发率(0)与对照组(6.25%)比较,差异无统计学意义(P > 0.05)。治疗后,观察组CRP、TNF-α、ESR明显降低,且低于对照组,组间比较差异有统计学意义(P < 0.05)。 结论 慢性骨髓炎患者采取负压封闭引流、臭氧生理盐水冲洗联合载敏感抗生素硫酸钙治疗有利于清除细菌,降低炎症因子及血沉水平,促使创面愈合,获得确切的疗效,值得推广。
英文摘要:
      [Abstract] Objective To investigate the efficacy of vacuum sealing drainage (VSD) and ozone saline flushing combined with sensitive antibiotic calcium sulfate in the treatment of chronic osteomyelitis. Methods A total of 45 patients with chronic osteomyelitis admitted to the Seventh Affiliated Hospital of Southern Medical University from January 2020 to August 2021 were selected as the study objects and divided into two groups by random number table method. 22 patients in the control group received vancomycin-loaded calcium sulfate, while 23 patients in the observation group received VSD and ozone saline flushing combined with sensitive antibiotic-loaded calcium sulfate. The treatment effect, bacterial clearance rate and recurrence rate of osteomyelitis were compared. C-reactive protein (CRP), tumor necrosis factor-α (TNF-α) and Erythrocyte sedimentation rate (ESR) were measured before and after treatment. Results The total effective rate of the observation group (95.65%) was higher than that of the control group (72.73%), and the bacterial clearance rate (95.65%) was higher than that of the control group (68.18%), with statistically significant differences (P < 0.05). There was no statistically significant difference between the recurrence rate of the observation group (0) and the control group (6.25%) (P > 0.05). After treatment, CRP, TNF-α and ESR in the observation group decreased significantly, and were lower than those in the control group, with statistically significant differences (P < 0.05). Conclusion The treatment of chronic osteomyelitis patients with VSD and ozone saline flushing combined with sensitive antibiotics-loaded calcium sulfate is beneficial to clearing bacteria, reducing inflammatory factors and erythrocyte sedimentation rate, promoting wound healing, and obtaining a definite treatment effect, which is worth popularizing.
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