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靳朝国,李华,詹义兵,赵军华.自体富血小板血浆联合植皮治疗皮肤软组织缺损的效果[J].中国医药科学,2022,(20):139-142        基金项目:
自体富血小板血浆联合植皮治疗皮肤软组织缺损的效果
Effect of skin soft tissue defect with autologous platelet-rich plasma combined with skin grafting
  
DOI:
中文关键词:  富血小板血浆;植皮;皮肤软组织缺损;创伤
英文关键词:Platelet-rich plasma; Skin graft; Skin soft tissue defect; Trauma
作者单位
靳朝国,李华,詹义兵,赵军华 湖北省荆州市第三人民医院骨科,湖北荆州 434001 
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中文摘要:
      [摘要] 目的 探讨自体富血小板血浆(PRP)联合植皮治疗创伤后皮肤软组织缺损的临床效果。 方法 选取2018年10月至2021年5月就诊于荆州市第三人民医院48例创伤导致皮肤软组织缺损的患者。随机分成研究组和对照组,每组各24例,对照组清创后常规换药,待创面肉芽形成后手术植皮。研究组清创后均应用PRP促进肉芽生长,待创面肉芽组织丰富覆盖创面后,再进行手术植皮修复。观察适合植皮时间、创面愈合时间、植皮后皮片成活率、创面愈合优良率,术后随访观察创面完全愈合后瘢痕情况。 结果 研究组适合植皮时间、创面愈合时间短于对照组,差异有统计学意义(P < 0.05);研究组的皮片成活率、创面愈合优良率明显高于对照组,差异有统计学意义(P < 0.05);所有患者均获得随访,随访时间6个月。6个月后研究组的血管分布、瘢痕色泽、瘢痕厚度、瘢痕柔软度评分及温哥华瘢痕量表(VSS)总评分均低于对照组,差异有统计学意义(P < 0.05)。 结论 PRP联合植皮治疗皮肤软组织缺损对其他部位组织损伤小,能加快创面愈合时间,降低手术风险,提高整体安全性,具有很好的临床疗效。
英文摘要:
      [Abstract] Objective To investigate the clinical efficacy of autologous platelet-rich plasma (PRP) combined with skin grafting in the treatment of skin and soft tissue defects after trauma. Methods From October 2018 to May 2021, 48 patients with skin and soft tissue defects caused by trauma in the Third People’s Hospital of Jingzhou were selected. They were randomly divided into the study group and the control group, with 24 cases in each group. The control group underwent routine dressing change after debridement and skin grafting after granulation formation of the wound. After debridement, PRP was applied to promote granulation growth in all the study groups. After the granulation tissue of the wound was rich and covered the wound, surgical skin grafting was performed for repair. The appropriate skin grafting time, wound healing time, skin graft survival rate after skin grafting, and excellent and good wound healing rate were observed. Follow-up was performed to observe the scar after the wound healed completely. Results The suitable skin grafting time and wound healing time in the study group were shorter than those in the control group, and the differences were statistically significant (P < 0.05). The skin graft survival rate and the excellent and good wound healing rate in the study group were significantly higher than those in the control group, and the differences were statistically significant (P < 0.05). All patients were followed up six months. Six months later, the vascular distribution, scar color, scar thickness, scar softness score and total VSS score of the study group were lower than those of the control group, and the differences were statistically significant (P < 0.05). Conclusion PRP combined with skin grafting in the treatment of skin and soft tissue defects has little tissue damage in other parts, accelerates wound healing time, reduces surgical risk, improves overall safety, and has good clinical efficacy.
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