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林梅英1,刘益峰2▲,邹奇锋1,陈友伟1,曾海1.华蟾素注射液联合疗法治疗中晚期非小细胞肺癌的meta分析[J].中国医药科学,2022,(20):58-62        基金项目:
华蟾素注射液联合疗法治疗中晚期非小细胞肺癌的meta分析
Meta-analysis of cinobufotalin injection combined therapy on advanced non-small cell lung cancer
  
DOI:
中文关键词:  华蟾素;非小细胞肺癌;meta分析;注射液
英文关键词:Cinobufotalin; Non-small cell lung cancer; Meta analysis; Injection
作者单位
林梅英1,刘益峰2▲,邹奇锋1,陈友伟1,曾海1 1.福建省莆田市第一医院药学部,福建莆田 351100;2.联勤保障部队第九〇〇部队莆田医疗区普外科,福建莆田 351100 
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中文摘要:
      [摘要] 目的 系统评价华蟾素注射液联合疗法对中晚期非小细胞肺癌(NSCLC)的有效性及安全性。 方法 检索数据库有关华蟾素注射液联合疗法对中晚期NSCLC的试验,检索时间为建库至2021年12月。采用Review Manager 5.4进行meta 分析。 结果 最终纳入22项研究,总计1744例患者。meta分析结果显示,华蟾素注射液联合疗法能提高近期疗效和生存率、改善生活质量、缓解疼痛、降低不良反应。 结论 华蟾素注射液联合疗法治疗NSCLC临床有效率更高,不良反应更轻。
英文摘要:
      [Abstract] Objective To systematically evaluate the efficacy and safety of cinobufotalin injection combined therapy on advanced non-small cell lung cancer (NSCLC). Methods The database was searched for the trials of cinobufotalin injection combined therapy on advanced NSCLC, and the search time was from the establishment of the database to December 2021. Meta-analysis was conducted with Review Manager 5.4. Results Finally, 22 studies were included, with a total of 1744 patients. Meta-analysis showed that cinobufotalin injection combined therapy increased the short-term efficacy and survival rate, improved the quality of life, relieved pain and reduced adverse reactions. Conclusion The cinobufotalin injection combined therapy on advanced NSCLC has a higher clinical effective rate and causes fewer adverse reactions.
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