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刘锁红,迟戈夫▲,冯金章.肺炎链球菌性疾病防治的研究进展[J].中国医药科学,2022,(20):42-45        基金项目:国家自然科学基金(82060766)
肺炎链球菌性疾病防治的研究进展
Research progress in prevention and treatment of pneumococcal diseases
  
DOI:
中文关键词:  肺炎链球菌;疾病;疫苗;抗菌药物
英文关键词:Streptococcus pneumoniae; Illness; Vaccine; Antimicrobial agents
作者单位
刘锁红,迟戈夫▲,冯金章 内蒙古医科大学附属医院全科医学科,内蒙古呼和浩特  010000 
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中文摘要:
      [摘要] 肺炎链球菌(SP)是致病性较高的病原菌之一,流行范围广,能够引起多种肺炎链球菌性疾病(PD),已经给全球公共卫生造成了巨大疾病负担。目前,针对SP感染的治疗和预防方案主要是抗生素治疗及疫苗预防。到目前为止,已有多种血清型及非血清型疫苗与通过抑制溶血素(PLY)和/或分选酶A(SrtA)活性等机制来抵抗SP感染的药物被研发,其中PPV23及PCV13等疫苗已投入使用,部分新型疫苗及治疗药物也已进入临床试验,并有良好的安全性和疗效,这些疫苗和药物有望为PD的防治提供新的研究方向。
英文摘要:
      [Abstract] Streptococcus pneumoniae (SP) is one of the pathogenic bacteria with high pathogenicity. It has a wide epidemic range and can cause a variety of pneumococcal diseases (PD), leading to a huge burden of diseases to the global public health. At present, the treatment and prevention programs for SP infection are mainly antibiotic treatment and vaccine prevention. Up to now, a variety of serotype and non-serotype vaccines and drugs to resist SP infection by inhibiting pneumolysin (PLY) and/or SrtA activity have been developed, among which vaccines such as PPV23 and PCV13 have been put into use, and some new vaccines and therapeutic drugs have entered clinical trials, having good safety and efficacy. These vaccines and drugs are expected to provide a new research direction for the prevention and treatment of PD.
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