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金倩晨△,姜佳宁,吕金燕▲,王若雨,王刚.阿特珠单抗、贝伐珠单抗联合化疗治疗EGFR-TKIs耐药后晚期非小细胞肺癌1例并文献复习[J].中国医药科学,2021,(4):239-241        基金项目:
阿特珠单抗、贝伐珠单抗联合化疗治疗EGFR-TKIs耐药后晚期非小细胞肺癌1例并文献复习
A case report and literature review of atezolizumab and bevacizumab combined with chemotherapy for advanced non-small cell lung cancer after TKIs resistance
  
DOI:
中文关键词:  [关键词] 非小细胞肺癌;EGFR T790M;药物耐药;联合治疗
英文关键词:[Key words] Non-small cell lung cancer; EGFR T790M; Drug resistance; Combined treatment
作者单位
金倩晨△,姜佳宁,吕金燕▲,王若雨,王刚 大连大学附属中山医院肿瘤科,辽宁大连 116000 
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中文摘要:
      [摘要] 肺癌是发病率和病死率均较高的恶性实体肿瘤,其中非小细胞肺癌(NSCLC)占80%~90%。表皮生长因子受体酪氨酸激酶抑制剂(EGFR-TKIs)使用后普遍会出现获得性耐药,EGFR T790M突变是其耐药的主要原因,第三代TKIs的代表药物奥希替尼可针对EGFR T790M突变。免疫检查点抑制剂作为新兴的治疗方式,因其疗效显著和持久应答,为晚期NSCLC的治疗开创了新时代。本研究回顾性分析1例使用阿特珠单抗、贝伐珠单抗联合化疗治疗晚期NSCLC患者,旨在探讨三代EGFR-TKIs获得性耐药情况下,联合治疗获益的可能性。
英文摘要:
      [Abstract] Lung cancer is a malignant solid tumor with relatively high incidence of morbidity and mortality, among which non-small cell lung cancer (NSCLC) accounts for 80% to 90%. Acquired resistance generally occurs after the use of tyrosine kinase inhibitors (TKIs). The mutation of EGFR T790M is the main reason for its drug resistance. Osimertinib, the representative drug of the third generation TKIs, can target EGFR T790M mutation. As a new treatment method, immunosuppressive checkpoint inhibitors have created a new era for the treatment of advanced NSCLC because of its remarkable therapeutic efficacy and persistent reaction. In this paper, a case of advanced NSCLC treated with atezolizumab and bevacizumab combined with chemotherapy was analyzed retrospectively, in order to investigate the possibility of benefit of combined treatment in the case of acquired drug resistance of three generations of TKIs.
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