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耿立惠.哌拉西林/他唑巴坦致白细胞下降和发热两例病例报告[J].中国医药科学,2021,(4):236-238        基金项目:
哌拉西林/他唑巴坦致白细胞下降和发热两例病例报告
Report of two cases of leukopenia and fever caused by piperacillin/tazobactam
  
DOI:
中文关键词:  [关键词] 哌拉西林/他唑巴坦;疗程>10 d;累积量>150 g;血液系统不良反应
英文关键词:[Key words] Piperacillin/tazobactam; Treatment course >10 days; Cumulative dosage >150 g; Adverse reactions
作者单位
耿立惠 江苏省宿迁市第一人民医院呼吸科,江苏宿迁 223800 
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中文摘要:
      [摘要] 本文通过对两例使用哌拉西林/他唑巴坦抗感染,致白细胞下降和发热的社区获得性肺炎患者的医嘱进行回顾和血液学监测,及时发现哌拉西林/他唑巴坦对血液系统的不良反应。通过文献复习,了解使用哌拉西林/他唑巴坦用药疗程>10 d,累积量>150 g的患者需要密切监测血常规变化,并观察临床有无发热等不适症状,一旦发现药物不良反应,应及时停药,调整治疗方案,避免造成不良后果。
英文摘要:
      [Abstract] In this paper, the adverse reactions (ADRs) of piperacillin/tazobactam to the blood system were found in time by reviewing the doctor's advice and hematology monitoring of two cases of patients with community-acquired pneumonia who were treated with piperacillin/tazobactam to resist infection, leukopenia and fever. Through literature review, it is necessary to closely monitor the blood routine changes of patients with piperacillin/tazobactam treatment course for more than 10 days and cumulative amount for more than 150 g, and observe whether there is any clinical discomfort such as fever. Once ADRs of drugs are discovered, the drugs should be withdrawn in time and the treatment plan should be adjusted to avoid adverse consequences.
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