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张梅燕,刘英霞,陈丽红.eIF4E蛋白在乳腺癌组织中的表达及其意义[J].中国医药科学,2021,(4):183-186        基金项目:[基金项目] 广东省惠州市医疗卫生类科技计划项目(2019Y098)
eIF4E蛋白在乳腺癌组织中的表达及其意义
Expression of eIF4E protein in breast cancer tissue and its significance
  
DOI:
中文关键词:  [关键词] eIF4E蛋白;乳腺纤维腺瘤;乳腺浸润性导管癌;阳性表达率
英文关键词:[Key words] eIF4E protein; Breast fibroadenoma; Invasive ductal carcinoma of breast; Positive expression rate
作者单位
张梅燕,刘英霞,陈丽红 广东省惠州市第一人民医院病理科,广东惠州 516000 
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中文摘要:
      [摘要] 目的 分析在乳腺癌组织中eIF4E蛋白的表达及其意义。 方法 选取2019年1月至2020年1月惠州市第一人民医院收治的120例乳腺疾病患者,按照病理类型分组,60例乳腺纤维腺瘤患者纳入对照组,60例乳腺浸润性导管癌患者纳入研究组,所选研究对象均通过免疫组化S-P法对eIF4E蛋白表达予以检测,分析两组阳性表达率,并对eIF4E蛋白阳性表达与乳腺浸润性导管癌淋巴结转移及临床分期之间的关系进行分析。 结果 经检测,对照组eIF4E蛋白阳性表达28例,阳性表达率为46.67%,研究组eIF4E蛋白阳性表达52例,阳性表达率为86.67%,研究组eIF4E蛋白阳性表达率高于对照组,差异有统计学意义(P<0.05);在研究组患者中,36例存在淋巴结转移,其中eIF4E蛋白阳性表达36例,阳性表达率为100.00%,24例无淋巴结转移,其中eIF4E蛋白阳性表达16例,阳性表达率为66.67%,存在淋巴转移患者的eIF4E蛋白阳性表达率高于无淋巴转移患者,差异有统计学意义(P<0.05);在研究组患者中,24例临床分期为中晚期(Ⅲ期、Ⅳ期),其中eIF4E蛋白阳性表达23例,阳性表达率为95.83%,36例临床分期为早期(Ⅰ期、Ⅱ期),其中eIF4E蛋白阳性表达29例,阳性表达率为80.56%,中晚期患者eIF4E蛋白阳性表达率高于早期患者,差异有统计学意义(P<0.05)。 结论 对于乳腺癌患者来说,可以通过对组织中eIF4E蛋白表达进行检测,进而对乳腺纤维腺瘤以及乳腺浸润性导管癌进行鉴别诊断,而且还可以通过检测组织中eIF4E蛋白表达判断淋巴结转移、临床分期情况,具有显著临床价值。
英文摘要:
      [Abstract] Objective To analyze the expression of eIF4E protein in breast cancer tissue and its significance. Methods A total of 120 patients with breast diseases admitted to the Huizhou First People's Hospital from January 2019 to January 2020 were selected, and they were divided into the control group (n=60) and the study group (n=60) according to pathological types. Patients with breast fibroadenoma were included in the control group, while patients with invasive ductal carcinoma of breast were included in the study group. All the selected subjects were tested for expression of eIF4E protein by immunohistochemical S-P method, and the positive expression rate of the two groups was analyzed. Meanwhile, the relationship between positive expression of eIF4E protein with invasive ductal carcinoma of breast lymph node metastasis and clinical stage was analyzed. Results After detection, with the positive expression of eIF4E protein there were 28 cases and accounting for 46.67% in the control group, lower than 52 cases and accounting for 86.67% in the study group (P<0.05). In the study group, there were 36 cases with lymph node metastasis, among which 36 cases were positive for eIF4E protein, with a positive expression rate of 100.00%, while there was no lymph node metastasis in 24 cases, among which eIF4E protein was positive in 16 cases, with a positive expression rate of 66.67%. The positive expression rate of eIF4E protein in patients with lymph node metastasis was higher than that in patients without lymph node metastasis (P<0.05). Among the patients in the study group, 24 patients were in middle and late-stage (stage Ⅲ and stage Ⅳ), among which 23 cases were positive for eIF4E protein, and the positive expression rate was 95.83%. While 36 patients were in early stage (stageⅠand stageⅡ), among which 29 cases were positive for eIF4E protein, and the positive expression rate was 80.56%. Meanwhile, the positive expression rate of eIF4E protein in middle and late-stage patients was higher than that in early-stage patients (P<0.05). Conclusion For breast cancer patients, the differential diagnosis of breast fibroadenoma and invasive ductal carcinoma can be made by detecting the expression of eIF4E protein in tissues, and lymph node metastasis and clinical staging can be judged by detecting the expression of eIF4E protein in tissues, which has significant clinical value.
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