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张冠峰.硫酸镁联合硝苯地平与单用硫酸镁治疗妊娠高血压综合征的效果比较[J].中国医药科学,2021,(4):74-77        基金项目:
硫酸镁联合硝苯地平与单用硫酸镁治疗妊娠高血压综合征的效果比较
Comparative study on the effect between magnesium sulfate combined with nifedipine and magnesium sulfate alone in the treatment of pregnancy induced hypertension
  
DOI:
中文关键词:  [关键词] 妊高征;硫酸镁;硝苯地平;治疗效果;血压控制效果;脐动脉阻力指数;血黏度;妊娠结局
英文关键词:[Key words] Pregnancy induced hypertension; Magnesium sulfate; Nifedipine; Therapeutic effect; Control effect of
作者单位
张冠峰 山东省泰安市妇幼保健院医务科,山东泰安 271000 
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中文摘要:
      [摘要] 目的 分析硫酸镁联合硝苯地平与单用硫酸镁治疗妊娠高血压综合征(简称妊高征)的效果。 方法 选取泰安市妇幼保健院2018年6月至2020年1月收治的86例妊高征患者,根据患者入院先后顺序将其分为对照组和研究组。对照组43例予以单一的硫酸镁治疗,研究组43例患者在硫酸镁治疗基础上联合硝苯地平治疗,比较两组患者治疗效果以及妊娠不良结局总发生率,同时观察其治疗前后的血压指标变化、脐动脉阻力指数变化及血黏度变化。 结果 研究组治疗总有效率为93.02%,高于对照组的76.74%,差异有统计学意义(P<0.05)。研究组的妊娠不良结局总发生率为4.65%,低于对照组的23.26%,差异有统计学意义(P<0.05)。治疗前,两组血压指标、脐动脉阻力指数及血黏度比较,差异无统计学意义(P>0.05);治疗后,两组患者的血压指标、脐动脉阻力指数及血黏度均有明显下降,且研究组各指标均显著低于对照组,差异有统计学意义(P<0.05)。 结论 在妊高征患者的临床治疗中,相较于单一的硫酸镁治疗,在硫酸镁治疗基础上联合硝苯地平治疗可以进一步提高患者的临床疗效,在强化患者血压控制效果的同时还可以更大程度上降低脐动脉阻力指数以及血黏度,对改善其妊娠结局具有重要作用。
英文摘要:
      [Abstract] Objective To analyze the effect of magnesium sulfate combined with nifedipine and magnesium sulfate alone on pregnancy induced hypertension (PIH). Methods A total of 86 patients with PIH admitted to Tai'an Maternal and Child Health Hospital from June 2018 to January 2020 were selected as objects and they were divided into the control group (n=43) and the study group (n=43) according to the order of admission. The control group was treated with magnesium sulfate, while the study group was treated with nifedipine with magnesium sulfate. The treatment effect and the total incidence of adverse pregnancy outcomes were compared between the two groups, and the changes of blood pressure index, umbilical artery resistance index and blood viscosity were observed before and after treatment. Results The total effective rate of the study group was 93.02%, higher than 76.74% of the control group (P<0.05). The total incidence of adverse pregnancy outcomes in the study group was 4.65%, lower than 23.26% in the control group (P<0.05). Before treatment, there was no significant difference in blood pressure index, umbilical artery resistance index and blood viscosity between the two groups (P>0.05). After treatment, the blood pressure index, umbilical artery resistance index and blood viscosity of the two groups decreased significantly, and the indexes of the study group were significantly lower than those of the control group, with statistically significant differences (P<0.05). Conclusion In the clinical treatment of PIH patients, compared with magnesium sulfate alone, magnesium sulfate combined with nifedipine can further improve the clinical efficacy of patients, strengthen the blood pressure control effect, and reduce umbilical artery resistance index and blood viscosity to a greater extent, which play a crucial role in improving their pregnancy outcome.
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