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卢丹,祝淡抹,单委,刘艳芝,吴雅娟.胰岛素样生长因子和胰岛素样生长因子结合蛋白-3与胎儿生长受限的关系[J].中国医药科学,2021,(4):9-12        基金项目:[基金项目] 江苏省妇幼健康科研项目(F201809)
胰岛素样生长因子和胰岛素样生长因子结合蛋白-3与胎儿生长受限的关系
Correlation between insulin-like growth factor and insulin-like growth factor binding protein-3 and fetal growth restriction
  
DOI:
中文关键词:  [关键词] 胰岛素样生长因子-1;胰岛素样生长因子-2;胰岛素样生长因子结合蛋白-3;胎儿生长受限
英文关键词:[Key words] Insulin-like growth factor-1; Insulin-like growth factor-2; Insulin-like growth factor binding
作者单位
卢丹,祝淡抹,单委,刘艳芝,吴雅娟 扬州大学医学院,江苏扬州 225000 
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中文摘要:
      [摘要] 目的 检测胰岛素样生长因子-1、2(IGF-1、2)和胰岛素样生长因子结合蛋白-3(IGFBP-3)水平,分析IGF-1、2和IGFBP-3的含量变化与胎儿生长受限(FGR)的关系。 方法 选取2011年1月至2013年12月在苏北人民医院妇产科住院,诊断为FGR的孕妇36例及同期住院的正常妊娠妇女30例作为受试对象。采用酶联免疫吸附法(ELISA法)检测36例FGR孕妇(试验组)和30例正常妊娠女性(对照组)外周血和脐静脉血中IGF-1、2和IGFBP-3的浓度,并比较两组新生儿体重。结果 试验组孕妇血清及新生儿脐血IGF-1、2和IGFBP-3水平均低于对照组(P<0.05)。孕妇血清IGF-1、2和IGFBP-3水平均高于新生儿脐血IGF-1、2和IGFBP-3水平(P<0.05)。试验组的新生儿体重明显小于对照组(P<0.05)。 结论 IGF-1、2和IGFBP-3这三个因子可能是导致FGR发生发展的重要因素之一,可作为判断胎儿生长发育的一项客观指标。
英文摘要:
      [Abstract] Objective To detect the levels of insulin-like growth factors 1, 2 (IGF-1,2) and insulin-like growth factor binding protein-3 (IGFBP-3), and to analyze the correlation between the changes of IGF-1, 2 and IGFBP-3 and fetal growth restriction (FGR). Methods In this experiment, pregnant women diagnosed as FGR and normal pregnant women hospitalized and admitted to the department of obstetrics and gynecology of Northern Jiangsu People's Hospital during the same period from January 2011 to December 2013 were selected as research objects, and they were divided into the experimental group (n=36, pregnant women diagnosed as FGR) and the control group (n=30, normal pregnant women). Enzyme-linked immunosorbent assay (ELISA) was used to detect the concentrations of IGF-1, 2 and IGFBP-3 in peripheral blood and umbilical vein blood in the experimental group and the control group , and compare the neonatal weight between two groups. Results The levels of IGF-1, 2 and IGFBP-3 in pregnant women's serum and neonatal cord blood in the experimental group, and compare thde neonatal weight between two groups were lower than those in the control group (P<0.05). The levels of serum IGF-1, 2 and IGFBP-3 in pregnant women were higher than those in neonatal cord blood (P<0.05). The neonatal weights of the experimental group were significantly lower than those of the control group (P<0.05). Conclusion IGF-1, 2 and IGFBP-3 may be one of the key factors leading to the occurrence and development of FGR. Therefore, it can be used as an objective index to judge fetal growth and development.
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