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李浩宇,刘超,侯飞,刀钰洋,王昀,邓智勇▲.分化型甲状腺癌患者131I治疗前停服左旋甲状腺激素后血脂、血压与甲状腺功能的相关性分析[J].中国医药科学,2021,(4):1-4        基金项目:[基金项目] 国家自然科学基金(81860312;81960322);云南省科技计划项目(昆医联合专 项)[2018FE001(-247)];昆明医科大学研究生创新基金(2020S218)
分化型甲状腺癌患者131I治疗前停服左旋甲状腺激素后血脂、血压与甲状腺功能的相关性分析
Analysis of the correlations between blood lipid, blood pressure and thyroid function in patients with differentiated thyroid carcinoma after the withdrawal of L-T and before I treatment
  
DOI:
中文关键词:  [关键词] 分化型甲状腺癌;甲状腺功能减退;血脂;血压
英文关键词:[Key words] Differentiated thyroid carcinoma; Hypothyroidism; Blood lipid; Blood pressure
作者单位
李浩宇,刘超,侯飞,刀钰洋,王昀,邓智勇▲ 云南省肿瘤医院核医学科,云南昆明 650118 
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中文摘要:
      [摘要] 目的 探讨分化型甲状腺癌(DTC)患者131I治疗前停服左旋甲状腺激素(L-T4)后血脂、血压与甲状腺功能的相关性。 方法 回顾性分析云南省肿瘤医院116例DTC患者停服L-T4前后的甲状腺功能与血脂、血压的相关性。 结果 停药后甲减组三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(CHOL)、载脂蛋白B(ApoB)及舒张压(DBP)均高于停药前正常组,甲减组载脂蛋白A/载脂蛋白B(ApoA/ApoB)低于正常组(P<0.05)。甲减组高血压患病率(42.2%)高于正常组(29.3%)(P=0.040)。甲减组与正常组促甲状腺素(TSH)水平与各血脂及血压指标间均无明显相关性(P>0.05)。停药后甲减组患者分为TSH<50 μIU/ml组和TSH≥50 μIU/ml组,两组的血脂、血压水平及高血压患病率比较,差异均无统计学意义(P>0.05)。 结论 DTC患者131I治疗前停服L-T4后发生甲状腺功能减退时血脂及血压均发生异常,甲状腺功能减退达一定程度后血脂及血压变化不大。
英文摘要:
      [Abstract] Objective To investigate the correlations between blood lipid (BL), blood pressure (BP) and thyroid function in the patients with differentiated thyroid carcinoma (DTC) after the withdrawal of L-T and before 131I 4treatment. Methods The correlations between BL, BP and thyroid function before and after the withdrawal of L-T 4from 116 patients with DTC in Yunnan Cancer Hospital were analyzed retrospectively. Results After drug withdrawal, the levels of triglyceride(TG), low density lipoprotein cholesterol(LDL-C), total cholesterol(CHOL), apolipoprotein B(ApoB) and diastolic blood pressure(DBP) in the hypothyroidism group were all higher than those in the normal group before drug withdrawal, and the levels of the apolipoprotein A/apolipoprotein B(ApoA/ApoB) in the hypothyroidism group were lower than those in the normal group (P < 0.05). The prevalence of hypertension in the hypothyroidism group (42.2%) was higher than that in the normal group (29.3%) (P=0.040). There were no significant correlations between the TSH level and the indices of BL and BP in both the hypothyroidism group and the normal group (P>0.05). After drug withdrawal, the patients with hypothyroidism were divided into the TSH<50 μIU/ml group and the TSH ≥ 50 μIU/ml group. The results showed that there were no statistically significant differences in the levels of BL and BP and the prevalence of hypertension between the two groups (P>0.05). Conclusion After the withdrawal of L-T and before 131I treatment, DTC patients exhibit abnormal BL and BP when hypothyroidism occurs. 4No significant change in BL and BP after hypothyroidism reached a certain degree.
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