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黄涌.美托洛尔与辛伐他汀对心肌梗死患者的应用及患者心功能指标的影响[J].中国医药科学,19,(14):35-37        基金项目:
美托洛尔与辛伐他汀对心肌梗死患者的应用及患者心功能指标的影响
Application of metoprolol and simvastatin in patients with myocardial infarction and its effect on cardiac function indexes
  
DOI:
中文关键词:  美托洛尔;辛伐他汀;心肌梗死;左心室射血分数;心功能
英文关键词:Metoprolol;Simvastatin;Myocardial infarction;Left ventricular ejection fraction;Cardiac function
作者单位
黄涌 广西壮族自治区容县中医院内一科,广东容县 537500 
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中文摘要:
      目的 探讨美托洛尔与辛伐他汀对心肌梗死患者的应用及患者心功能指标的影响。 方法 选取我院2016 年 4 月~ 2017 年 9 月收治的心肌梗死患者 96 例,采用随机数字表法分为两组,每组 48 例,对照组给予患者美托洛尔药物治疗,研究组在对照组的基础上再给予患者辛伐他汀治疗。观察比较两组心肌梗死患者的治疗效果、心脏功能改善情况以及心脑血管相关事件发生情况。 结果 研究组患者治疗效果显著优于对照组(P < 0.05);研究组患者左心室舒张末期内径、左心室收缩末期内径以及左心室射血分数均低于对照组(P < 0.05),研究组患者心脏功能优于对照组(P < 0.05),研究组患者的主要心脑血管相关事件发生 率均低于对照组(P < 0.05)。 结论 对心肌梗死患者治疗过程中,应用美托洛尔和辛伐他汀,可以显著提高临床治疗效果,并且大大改善了心肌梗死患者的心脏功能,降低患者心脑血管相关事件发生率。
英文摘要:
      Objective To explore the application of metoprolol and simvastatin in patients with myocardial infarction and its effect on cardiac function indexes. Methods 96 patients with myocardial infarction who were admitted and treated in our hospital from April 2016 to September 2017 were selected.They were randomly divided into two group according to the random number table method,with 48 cases in each group.The control group was treated with metoprolol while the study group was treated with simvastatin on the basis of the control group.Curative effects,the improvement of cardiac function and the occurrence of cardiovascular and cerebrovascular related events of patients with myocardial infarction were observed and compared between the two groups. Results The curative effect of the study group was significantly better than that of the control group(P < 0.05).Left ventricular end-diastolic diameter,left ventricular end-systolic diameter and left ventricular ejection fraction of the study group were lower than those of the control group(P < 0.05).The cardiac function of the study group was better than that of the control group (P < 0.05).The incidence of major cardiovascular and cerebrovascular events of the study group was lower than that of the control group(P < 0.05). Conclusion The application of metoprolol and simvastatin in the treatment of patients with myocardial infarction can significantly improve the clinical curative effect,greatly improve the cardiac function of patients with myocardial infarction and reduce the incidence of cardiovascular and cerebrovascular related events.
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