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于琦,付塬,樊金宇,修云霞▲.住院乳腺癌合并肺部感染患者血清炎性因子与NT-ProBNP的改变分析[J].中国医药科学,2020,(1):213-215        基金项目:
住院乳腺癌合并肺部感染患者血清炎性因子与NT-ProBNP的改变分析
Analysis on changes of serum inflammatory factors and NTProBNP in hospitalized women with breast cancer complicated with pulmonary infection
  
DOI:
中文关键词:  降钙素原;C- 反应蛋白;白细胞介素 -6;乳腺癌;肿瘤坏死因子 -α;白细胞介素 -1β;N 末 端脑钠肽
英文关键词:Procalcitonin; C-reactive protein; Interleukin-6; Breast cancer; Tumor necrosis factor-α; Interleukin- 1β; N-terminal brain natriuretic peptide
作者单位
于琦,付塬,樊金宇,修云霞▲ 牡丹江医学院附属第二医院检验科,黑龙江牡丹江 157009 
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中文摘要:
      [摘要] 目的 探讨住院乳腺癌合并肺部感染患者血清炎性因子与 NT-ProBNP 的改变情况。方法 选取自2013 年 10 月~ 2017 年 10 月在我院接受治疗的乳腺癌患者 80 例,根据患者是否合并肺部感染将其分为两组,乳腺癌合并肺部感染组 24 例作为研究组;单纯乳腺癌非合并肺部感染组 56 例作为参照组。对两组的炎性因子及 NT-proBNP 的表达水平进行统计分析,统计两组的年龄、糖尿病史、体重和病程。 结果 研究组患者的 PCT、CRP 与 IL-6 表达水平分别为(3.47±0.63)ng/L,(37.56±7.22)mg/L,(44.15±12.52)ng/L,均明显高于参照组患者,P < 0.05;研究组患者的 TNF-α、IL-1β 及 NT-proBNP 的表达水平分别为(11.13±4.67)μg/L,(10.09±5.72)μg/L,(14.15±6.06)μg/L,均显著高于参照组患者,P < 0.05;两组患者年龄、体重、病程及有无糖尿病史等临床资料比较差异无统计学意义(P > 0.05)。 结论 乳腺癌合并肺部感染患者的血清炎性因子及 NT-proBNP 表达高于非肺部感染患者。因此血清炎性因子和 NT-proBNP 或可以作为乳腺癌合并肺部感染的有效诊断指标。
英文摘要:
      [Abstract] Objective To explore changes of serum inflammatory factors and NT-ProBNP in hospitalized women with breast cancer complicated with pulmonary infection. Methods 80 patients with breast cancer who were treated in our hospital from October 2013 to October 2017 were selected. According to whether the patients were complicated with pulmonary infection or not, they were divided into the study group (breast cancer complicated with pulmonary infection) with 24 cases and the control group (breast cancer without complication of pulmonary infection) with 56 cases. Statistical analysis was performed on the expression levels of inflammatory factors and NT-proBNP in both groups. The age, history of diabetes, weight and duration of disease of the two groups were counted. Results The expression levels of PCT, CRP and IL-6 in the study group were (3.47±0.63)ng/L, (37.56±7.22)mg/L, (44.15±12.52)ng/L, all significantly higher than those in the control group, P < 0.05. The expression levels of TNF-α, IL-1β and NTproBNP in the study group were (11.13±4.67)μg/L, (10.09±5.72)μg/L, (14.15±6.06)μg/L, all significantly higher than those in the control group, P < 0.05. There was no difference in clinical data between the two groups in terms of age, weight, duration of disease and presence or absence of diabetes, P > 0.05. Conclusion The expression levels of serum inflammatory factors and NT-proBNP in patients with breast cancer complicated with pulmonary infection are higher than those in patients without pulmonary infection. Therefore, serum inflammatory factors and NT-proBNP may be used as an effective diagnostic indicator for breast cancer complicated with pulmonary infection.
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