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黎首豪,黄书炜,蔡玉青.新生儿急性呼吸窘迫综合征治疗中肺表面活性物质的疗效[J].中国医药科学,2020,(1):158-160        基金项目:
新生儿急性呼吸窘迫综合征治疗中肺表面活性物质的疗效
Curative effects of pulmonary surfactant in treatment of neonatal acute respiratory distress syndrome
  
DOI:
中文关键词:  新生儿;急性呼吸窘迫综合征;肺表面活性物质;血气指标
英文关键词:Neonates; Acute respiratory distress syndrome; Pulmonary surfactant; Blood gas index
作者单位
黎首豪,黄书炜,蔡玉青 广东省肇庆市端州区妇幼保健院儿科,广东肇庆 526040 
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中文摘要:
      [摘要] 目的 探讨新生儿急性呼吸窘迫综合征治疗中肺表面活性物质的疗效。 方法 选取 2017 年 1月~ 2019 年 1 月收治的急性呼吸窘迫综合征新生儿共计 80 例,按照随机数字表法将其分成研究组(n=40)和对比组(n=40),对比组新生儿行常规呼吸支持治疗,研究组新生儿在对比组基础上行肺表面活性物质治疗,对比分析不同组别新生儿机械通气时间、用氧时间、血气指标和治疗效果。结果 研究组新生儿的机械通气时间和用氧时间均低于对比组,差异有统计学意义(P < 0.05);两组新生儿治疗前各项血气指标比较差异无统计学意义(P > 0.05),但研究组新生儿的 PH 和 PaO2 均高于对比组、PaCO2 低于对比组,组间比较差异有统计学意义(P < 0.05);研究组新生儿治疗总有效率为 95.0%,对比组新生儿治疗总有效率为77.5%,研究组明显高于对比组,差异有统计学意义(P < 0.05)。结论 急性呼吸窘迫综合征新生儿应用肺表面活性物质治疗的效果更佳,可有效缩短机械通气和用氧时间,改善新生儿血气指标,可在临床中予以广泛推广并应用。
英文摘要:
      [Abstract] Objective To explore curative effects of pulmonary surfactant in treatment of neonatal acute respiratory distress syndrome. Methods Eighty newborns with acute respiratory distress syndrome who were admitted and treated from January 2017 to January 2019 were selected. According to the random number table, they were divided into the study group (n=40) and the control group (n=40). The newborns in the control group were given routine respiratory support therapy while newborns in the study group were given pulmonary surfactant therapy on the basis of control group. The mechanical ventilation, using oxygen time, blood gas index and curative effects of newborns in different groups were compared and analyzed. Results The mechanical ventilation time and using oxygen time of newborns in the study group were lower than those in the control group, which was significant by statistical analysis (P < 0.05). There was no difference in blood gas indexes between the two groups before treatment (P > 0.05). But PH and PaCO2 of newborns in the study group were higher than those in the control group and PaCO2 was lower than that in the control group. The difference between groups was statistically significant (P < 0.05). The total effective rate of neonatal treatment was 95.0% in the study group and 77.5% in the control group. The total effective rate of neonatal treatment in the study group was significantly higher than that in the control group, and the difference was statistically significant (P < 0.05). Conclusion The curative effect of pulmonary surfactant therapy in treatment of neonates with acute respiratory distress syndrome is better. It can effectively shorten the time of mechanical ventilation and oxygen use and improve neonatal blood gas index, which can be widely promoted and applied in clinical practice.
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