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陈小娜.茂名市新生儿维生素D水平现状及影响因素分析[J].中国医药科学,2020,(1):129-132        基金项目:
茂名市新生儿维生素D水平现状及影响因素分析
Analysis on current status and influencing factors of vitamin D levels in newborns in Maoming
  
DOI:
中文关键词:  新生儿;25-(OH)D;影响因素;流行病学
英文关键词:Newborns;25-(OH) D;Influencing factors;Epidemiology
作者单位
陈小娜 广东省茂名市妇幼保健院儿童保健科,广东茂名 525000 
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中文摘要:
      [摘要] 目的 分析茂名市新生儿维生素 D 水平现状及其影响因素。 方法 选取 2016 年 3 月~ 2019 年 3 月茂名市地区新生儿 1000 例作为研究对象。检测所有新生儿血清 25-(OH) D 水平,同时收集新生儿及产妇一般资料。分析所有新生儿维生素 D 缺乏状况。以血清 25-(OH) D < 20ng/mL(50nmol/L)记为维生素 D 缺乏,Logistic 回归分析患儿维生素 D 缺乏的影响因素。 结果 1000 例新生儿血清 25-(OH) D 平均值为(19.36±7.89)ng/mL,其中,86 例新生儿维生素 D 严重缺乏,平均值为(9.29±0.39)ng/mL,543 例新生儿维生素 D 轻度缺乏,平均值为(15.08±2.94)ng/mL,260 例新生儿维生素 D 不足,平均值为(24.97±2.78)ng/mL,111 例新生儿维生素 D 充足,平均值为(34.99±3.79)ng/mL,新生儿维生素 D 缺乏患病率为 62.90%。二元Logistic 回归结果显示,居住地(OR=1.582,95% CI =1.211 ~ 2.066,P=0.001)、教育程度(OR=0.628,95% CI =0.486 ~ 0.811,P=0.000)、日照时长(OR=1.539,95% CI =1.1816 ~ 2.006,P=0.001)、补充维生素 D 和钙剂情况(OR=1.571,95% CI =1.211 ~ 2.066,P=0.001)、分娩季节(OR=1.187,95% CI =1.046 ~ 1.347,P=0.008)是新生儿维生素 D 缺乏的影响因素。 结论 茂名市地区新生儿维生素 D 缺乏患病率较高,居住农村、 学历低、日照时长短、未常规补充维生素 D 和钙剂以及冬春季节分娩是新生儿维生素 D 缺乏的影响因素。
英文摘要:
      [Abstract] Objective To analyze current status and influencing factors of vitamin D levels in newborns in Maoming. Methods 100 newborns in Maoming from March 2016 to March 2019 were selected as research objects.Serum 25-(OH) D levels were measured in all neonates,and general information on neonates and maternal data was collected.Vitamin D deficiency status of all newborns were analyzed.Serum 25-(OH) D below 20ng/mL (50nmol/L) was recorded as vitamin D deficiency,and Logistic regression analysis was used to analyze the influencing factors of vitamin D deficiency in newborns. Results The mean serum 25-(OH) D of 1000 neonates was (19.36±7.89)ng/mL. Among them,86 neonates were seriously deficient in vitamin D (mean value:9.29±0.39 ng/mL), 543 neonates were mildly deficient in vitamin D (mean value: 15.08±2.94 ng/mL),260 neonates were deficient in vitamin D (mean value:24.97±2.78 ng/mL) and 111 neonates were adequate in vitamin D (mean value:34.99±3.79 ng/mL).The prevalence of neonatal vitamin D deficiency was 62.90%.Binary Logistic regression results showed that the place of residence (OR=1.582,95%CI=1.211 ~ 2.066,P=0.001),education level (OR=0.628,95%CI=0.486 ~ 0.811,P=0.000), sunshine duration (OR=1.539,95%CI=1.1816 ~ 2.006, P=0.001), vitamin D supplementation and calcium (OR=1.571,95%CI=1.211 ~ 2.066,P=0.001), delivery season (OR=1.187,95%CI=1.046 ~ 1.347,P=0.008) were influencing factor for vitamin D deficiency in newborns. Conclusion Prevalence of vitamin D deficiency in newborns in Maoming is high. Living in rural areas, low education, short length of sunshine, unconventional supplementation of vitamin D and calcium and delivery in winter and spring are factors influencing vitamin D deficiency in newborns.
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