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吴丽雅,赖淑梅,郭宽萍,赖清华.克拉霉素治疗生殖道衣原体感染的有效性及安全性观察[J].中国医药科学,2020,(1):114-116        基金项目:
克拉霉素治疗生殖道衣原体感染的有效性及安全性观察
Observation on the effectiveness and safety of clarithromycin in the treatment of genital chlamydia infection
  
DOI:
中文关键词:  克拉霉素;阿奇霉素;多西环素;生殖道衣原体感染
英文关键词:Clarithromycin;Azithromycin;Doxycycline;Genital chlamydia infection
作者单位
吴丽雅,赖淑梅,郭宽萍,赖清华 深圳市宝安区妇幼保健院妇科,广东深圳 518000 
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中文摘要:
      [摘要] 目的 探究克拉霉素治疗生殖道衣原体感染的有效性及安全性。 方法 选取我院 2018 年 3 ~ 12 月收治的生殖道衣原体感染患者 150 例,按随机数字表法分为 A 组(50 例)、B 组(50 例)及 C 组(50 例),分别给予口服克拉霉素片、阿奇霉素分散片及盐酸多西环素分散片进行治疗。比较三组患者治疗后的临床疗效、症状消退时间和生殖道衣原体清除率以及不良反应情况。 结果 三组患者治疗总有效率中 A 组患者明显高于 B、C 两组,组间比较差异有统计学意义(P < 0.05);A 组症状消退时间最快、衣原体清除率最高,三组间比较差异有统计学意义(P < 0.05);三组患者不良反应发生率分别为 6.00%、8.00% 及 12.00%,差异无统计学意义(P > 0.05)。 结论 克拉霉素治疗生殖道衣原体感染疗效显著,衣原体清除率高,且具有较高的安全性,值得临床推广应用。
英文摘要:
      [Abstract] Objective To investigate the effectiveness and safety of clarithromycin in the treatment of genital chlamydia infection. Methods 150 patients with genital chlamydia infection who were admitted to our hospital from March to December 2018 were selected as subjects of this study.The patients were divided into group A(50 cases),group B(50 cases)and group C(50 cases)according to the random number table method,and were treated with oral clarithromycin tablets,azithromycin dispersible tablets and doxycycline hydrochloride dispersible tablets respectively.The clinical efficacy,symptom regression time,clearance rate of genital chlamydia and adverse reactions after treatment were compared between the three groups. Results Among the three groups,the total effective rate of patients in group A was significantly higher than that in group B and C,and the differences between groups were statistically significant(P < 0.05).Group A showed the shortest symptom regression time and the highest clearance rate of chlamydia.The differences between the three groups was statistically significant(P < 0.05).The incidence of adverse reactions in the three groups were 6.00%,8.00% and 12.00%,respectively,and the differences were not statistically significant(P > 0.05). Conclusion Clarithromycin has shown significant efficacy,high clearance rate of chlamydia and high safety in the treatment of genital chlamydia infection,which is worthy of clinical application.
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