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邓健青.硝呋太尔栓应用于宫颈炎抗菌治疗中的效果及对炎性介质的影响[J].中国医药科学,2020,(1):104-107        基金项目:
硝呋太尔栓应用于宫颈炎抗菌治疗中的效果及对炎性介质的影响
Effects of nifuratel suppository in the treatment of cervicitis and its influence on inflammatory mediators
  
DOI:
中文关键词:  硝呋太尔栓;宫颈炎;白介素 -8;肿瘤坏死因子 -α
英文关键词:Nifuratel suppository;Cervicitis;Interleukin-8;Tumor necrosis factor-α
作者单位
邓健青 广东省陆丰市妇幼保健计划生育服务中心,广东陆丰 516500 
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中文摘要:
      [摘要] 目的 探讨硝呋太尔栓应用于宫颈炎抗菌治疗中的效果及对炎性介质的影响。 方法 将 2015 年 6月~ 2017 年 6 月广东省陆丰市妇幼保健计划生育服务中心收治的 96 例非淋菌性宫颈炎作为研究对象,依据随机数字表法分为观察组 48 例和对照组 48 例。对照组给予克拉霉素片 500mg/ 次,2 次 /d,连续治疗 2 周;观察组在对照组治疗基础上联合应用硝呋太尔栓规格 0.5g/ 粒,睡前置于阴道后苍穹处,1 次 / 粒,1 次 /d,连续治疗 2 周。比较两组患者临床效果、临床症状及体征改善情况,治疗前后 IL-8、TNF-α 变化水平,并记录两组患者不良反应发生情况。 结果 治疗后观察组总有效率为 95.8% 显著高于对照组的 81.3%(χ2=5.031,P=0.025);观察组在阴道分泌物消失时间、阴道流血消失时间及创面愈合时间明显低于对照组(t=5.695,4.529,7.673,P 均< 0.05);观察组 IL-8、TNF-α 明显低于对照组(t=2.940,26.776,P 均< 0.05);两组患者治疗过程中发生胃肠道反应、皮疹、头晕、心悸、转氨酶升高等不良反应,未发生其他严重不良反应,均未处理自行好转;两组间各不良反应发生率比较,差异无统计学意义(χ2=0.443,0.260,2.192,0.723,2.122,P 均> 0.05)。 结论 硝呋太尔栓应用于宫颈炎可提高抗菌效果,减轻炎性反应,安全性好,值得临床推广应用。
英文摘要:
      [Abstract] Objective To investigate the effect of Nifuratel suppository in the treatment of cervicitis and its influence on inflammatory mediators. Methods 96 cases of non-gonococcal cervicitis treated in Maternal and Child Health and Family Planning Service Center of Lufeng City from June 2015 to June 2017 were divided into observation group (n=48) and control group (n=48) using the random number table method.The control group was given clarithromycin tablets 500mg/time,twice a day for 2 weeks;The observation group was given Nifuratel suppository 0.5g/capsule on the basis of the treatment in the control group,which was placed in the posterior vault of vagina before sleeping,a capsule/time,once a day for 2 weeks.The clinical effects,clinical symptoms and signs improvement of the two groups were compared,the changes of interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) before and after treatment were compared,and the adverse reactions of the two groups were recorded. Results After treatment,the total effective rate of the observation group was 95.8%,which was significantly higher than that of the control group (81.3%) (χ2=5.031,P=0.025);The disappearance time of vaginal secretion,vaginal bleeding and wound healing time in the observation group were significantly shorter than those in the control group (t=5.695,4.529,7.673, P < 0.05);The IL-8 and TNF-α in the observation group were significantly lower than those in the control group (t=2.940,26.776, P < 0.05).There was no significant difference in gastrointestinal reaction,skin rash,dizziness, palpitation,transaminase elevation between the two groups (χ2=0.443,0.260,2.192,0.723,2.122,P > 0.05),and no and other serious adverse reactions occurred in the course of treatment,all of which were improved by themselves. Conclusion Nifuratel suppository can improve the antibacterial effect,reduce the inflammatory reaction,and has good safety in treating cervicitis.It is worthy of clinical application.
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