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李桂联.克龄蒙与米非司酮治疗绝经过渡期功能性子宫出血的疗效差异[J].中国医药科学,2020,(1):98-100        基金项目:
克龄蒙与米非司酮治疗绝经过渡期功能性子宫出血的疗效差异
Efficacy differences of Climen and mifepristone on functional uterine bleeding during menopausal transition period
  
DOI:
中文关键词:  绝经过渡期功能性子宫出血;克龄蒙;米非司酮;疗效
英文关键词:Functional uterine bleeding during menopausal transition period; Climen; Mifepristone; Efficacy
作者单位
李桂联 广东医科大学附属第三医院 (佛山市顺德区龙江医院),广东佛山 528318 
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中文摘要:
      [摘要] 目的 探讨克龄蒙与米非司酮治疗绝经过渡期功能性子宫出血的临床疗效。 方法 收集 2018 年 3月~ 2019 年 3 月我院接受治疗的 45 例绝经过渡期功能性子宫出血患者的临床资料并进行回顾性分析,按治疗方法分为对照组和观察组,对照组(n=22)与观察组(n=23)全部采用常规止血,在此基础上,分别服用米非司酮和克龄蒙治疗,评估两组临床疗效、比较两组止血时间和两组患者的性激素水平。 结果 (1)对照组 9 例治愈、7 例有效、6 例无效,总有效率为 72.73%;观察组中,治愈和有效的例数分别有 17 例、5 例,无效1 例,总有效率为 95.65%; 差异有统计学意义(P < 0.05)。(2)观察组的出血减少时间为(2.04±0.22)d、出血控制时间(5.32±0.85)d、出血完全停止时间(10.87±1.82)d;明显短于对照组(4.26±0.37)d、(9.47±0.35)d、(18.76±2.48)d,差异有统计学意义(P < 0.05)。(3)观察组患者的 FSH、LH 与 E2 水平明显低于对照组 . 差异有统计学意义(P < 0.05)。 结论 在绝经过渡期功能性子宫出血的临床治疗中,克龄蒙在临床疗效、调节雌激素、止血时间三方面要优于米非司酮,可为临床用药提供指导依据。
英文摘要:
      [Abstract] Objective To investigate the clinical efficacy of Climen and mifepristone in the treatment of functional uterine bleeding during menopausal transitionperiod. Methods The clinical data of 45 patients with functional uterine bleeding during menopausal transition period who were treated in our hospital from March 2018 to March 2019 were collected and retrospectively analyzed. The patients were divided into control group (n=22) and observation group (n=23) according to the treatment method. Both the control group and the observation group were given conventional hemostasis. On this basis, they were treated with mifepristone and Climen, respectively. The clinical efficacy was evaluated and the patient's hemostatic time and sex hormone levels were compared. Results (1) In the control group, 9 cases were cured, 7 cases were effective, 6 cases were ineffective, and the total effective rate was 72.73%. In the observation group, 17 cases and 5 cases were cured and effective respectively, 1 case was ineffective, and the total effective rate was 95.65%. The difference was statistically significant (P < 0.05). (2) The bleeding reduction time, bleeding control time and complete bleeding stop time of the observation group were (2.04±0.22) days, (5.32±0.85) days and (10.87±1.82) days, respectively, which were significantly shorter than the control group of (4.26±0.37) days, (9.47±0.35) days and (18.76±2.48) days, and the differences were statistically significant (P < 0.05). (3) The levels of FSH, LH and E2 in the observation group were significantly lower than those in the control group. The differences were also statistically significant (P < 0.05). Conclusion In the clinical treatment of functional uterine bleeding during menopausal transition period, Climen is superior to mifepristone in clinical efficacy, regulation of estrogen and hemostasis time, which can provide guidance for clinical use.
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