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冼文川,林力峰,林智君.拜阿司匹林联合氯吡格雷治疗急性轻型脑梗死的临床疗效及不良反应分析[J].中国医药科学,2020,(1):83-85        基金项目:
拜阿司匹林联合氯吡格雷治疗急性轻型脑梗死的临床疗效及不良反应分析
Analysis on clinical curative effects and adverse reactions of bayer aspirin combined with clopidogrel in treatment of acute mild cerebral infarction
  
DOI:
中文关键词:  急性脑梗死;阿司匹林;氯吡格雷;临床疗效;不良反应
英文关键词:Acute cerebral infarction;Aspirin;Clopidogrel;Clinical curative effects;Adverse reactions
作者单位
冼文川,林力峰,林智君 广东医科大学附属医院神经内科,广东湛江 524001 
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中文摘要:
      [摘要] 目的 观察拜阿司匹林联合氯吡格雷治疗急性轻型脑梗死的临床疗效及不良反应。 方法 选取 2015年 1 月~ 2016 年 12 月急性轻型脑梗死患者 70 例,采用随机数字表法分为联合用药组和单药组,各 35 例。联合用药组给予拜阿司匹林及氯吡格雷,单药组给予拜阿司匹林。对所有患者进行 NIHHS 评分,比较两组的临床疗效、神经功能及不良反应并观察其 90d 内的复发率。 结果 联合用药组治疗有效率显著高于单药组(P < 0.05),治疗前两组 NIHSS 评分差异无统计学意义(P > 0.05);治疗后两组患者的 NIHHS 评分明显下降(P < 0.05),但联合用药组显著低于单药组(P < 0.05)。联合用药组复发率为 2.9%(1/35),单药组为 17.1%(6/35),联合用药组复发率低于单药组,差异有统计学意义(P < 0.05)。两组患者在治疗过程未出现严重不良反应。 结论 拜阿司匹林联合氯吡格雷治疗急性轻型脑梗死疗效较好,使缺损神经功能得以改善,安全性较高,复发率低,值得临床推广应用。
英文摘要:
      [Abstract] Objective To observe the clinical curative effects and adverse reactions of Bayer aspirin combined with clopidogrel in treatment of acute mild cerebral infarction. Methods 70 patients with acute mild cerebral infarction from January 2015 to December 2016 were selected.They were divided into the combined medication group and the single medication group according to the random number table method,with 35 cases in each group.The combined medication group were given aspirin combined with clopidogrel while the single medication group were given Bayer aspirin.NIHHS scores were performed on all patients before and after treatment.The clinical curative effects,neurological function and adverse reactions were compared between two groups and the recurrence rate within 90 days were observed. Results The effective rate of treatment of the combined medication group was significantly higher than that in the single medication group(P < 0.05).There was no significant difference in NIHHS scores before treatment between the two groups(P > 0.05).After treatment,the NIHHS scores of the two groups were significantly ecreased(P < 0.05),but NIHHS score of the combined medication group was significantly lower than that of the single medication group(P < 0.05).The recurrence rate was 2.9%(1/35)in the combined medication group and 17.1%(6/35)in the single combined medication group.The recurrence rate of the combined medication group was lower than that of the single combined medication group.The difference was statistically significant(P < 0.05). Conclusion Bayer aspirin combined with clopidogrel in treatment of acute mild cerebral infarction has better curative effects,which can improve the symptoms of neurological deficit.It has higher safety and lower recurrence rate.It is worthy of clinical promotion and application.
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