| 张文昌，陈琳.替诺福韦治疗慢性重型乙型肝炎的临床疗效观察[J].中国医药科学,2020,(1):80-82 基金项目: |
| 替诺福韦治疗慢性重型乙型肝炎的临床疗效观察 |
| Observation on clinical curative effects of tenofovir in treatment of chronic severe hepatitis B |
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| DOI： |
| 中文关键词: 替诺福韦；谷胱甘肽；慢性重型乙型肝炎；丙氨酸氨基转移酶；肿瘤坏死因子 α；白细胞介素 10 |
| 英文关键词:Tenofovir;Glutathione;Chronic severe hepatitis B;Alanine aminotransferase;Tumor necrosis factor α;
Interleukin 10 |
| 作者 | 单位 | | 张文昌，陈琳 | 广西壮族自治区桂东人民医院药学部， 广西梧州 543001 |
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| 中文摘要: |
| [摘要] 目的 观察替诺福韦在治疗慢性重型乙型肝炎中的临床疗效，为慢性重型乙型肝炎患者临床治疗提供理论依据。 方法 选取我院 2018 年 7 月～ 2019 年 2 月收治的慢性重型乙型肝炎患者 68 例为本次研究对象，采用 EpiInfo 2000 版对患者进行随机分组，34 例对照组采用谷胱甘肽治疗，34 例观察组采用替诺福韦治疗，对比两组患者临床治疗效果。 结果 治疗前两组患者 TNF-α、IL-10、HBV-DNA、ALT 指标数据比较，差异无统计学意义（P ＞ 0.05）；治疗后观察组各项指标与对照组比较差异有统计学意义（P ＜ 0.05），观察组优于对照组；治疗后观察组 HBeAg 转阴率高于对照组，差异有统计学意义（P ＜ 0.05）。 结论 替诺福韦用于慢性重型乙型肝炎治疗有良好抗病毒效果，能够显著改善患者各项指标，临床应用前景广泛。 |
| 英文摘要: |
| [Abstract] Objective To observe clinical curative effects of tenofovir in treatment of chronic severe hepatitis
B and to provide theoretical basis for clinical treatment of patients with chronic severe hepatitis B. Methods 68
patients with chronic severe hepatitis B who were admitted and treated in our hospital from July 2018 to February
2019 were selected as research objects.They were randomly divided into two groups by EpiInfo 2000.34 patients in
the control group were treated with glutathione while 34 patients in the observation group were treated with tenofovir.Clinical curative effects of patients were compared between two groups. Results There was no statistically significant difference in the data of TNF-α,IL-10,HBV-DNA and ALT between the two groups before treatment (P ＞ 0.05).After treatment,the differences in the indexes between the observation group and the control group were statistically significant (P ＜ 0.05).The observation group was better than control group.After treatment, the negative rate of HBeAg in the observation group was higher than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Tenofovir in treatment of chronic severe hepatitis B has a good antiviral effect and it can significantly improve various indexes of patients.It has broad clinical application prospects. |
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