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徐大明1,李晖2▲,刘康1.齐拉西酮、利培酮治疗精神分裂症的效果及对性激素的影响分析[J].中国医药科学,2020,(1):77-79        基金项目:
齐拉西酮、利培酮治疗精神分裂症的效果及对性激素的影响分析
Analysis on curative effects of ziprasidone and risperidone in treatment of schizophrenia and their effects on sex hormone
  
DOI:
中文关键词:  齐拉西酮;利培酮;精神分裂症;性激素
英文关键词:Aiprasidone; Risperidone; Schizophrenia; Sex hormone
作者单位
徐大明1,李晖2▲,刘康1 1. 江苏省常州市解放军 904 医院心理科,江苏常州 213000;2. 江苏省常州市中医医院重症监护室,江苏常州 213003 
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中文摘要:
      [摘要] 目的 探讨分析齐拉西酮、利培酮治疗精神分裂症的效果及对性激素的影响。 方法 将 2017 年 11月~ 2018 年 11 月的 156 例精神分裂症患者应用随机数字表法分为实验组与对照组,并分别采用药物齐拉西酮和利培酮进行治疗,比较治疗效果。 结果 实验组治疗后患者的阳性与阴性症状量表(PANSS 量表)评分情况显著优于对照组,且实验组患者的血清睾酮、雌二醇及催乳素的性激素情况显著优于对照组,差异有统计学意义(P < 0.05)。 结论 采用齐拉西酮对患者进行治疗,能够提升治疗效果,且不会对患者的代谢情况和激素水平产生较大的影响,治疗效果显著。
英文摘要:
      [Abstract] Objective To explore and analyze curative effects of ziprasidone and risperidone in treatment of schizophrenia and their effects on Sex hormone. Methods 156 patients with schizophrenia from November 2017 to November 2018 were divided into experimental group and control group on average by random number table method. The experimental group was treated with ziprasidone while the control group was treated with risperidone. Curative effects were determined. Results The positive and negative symptom scale (PANSS) score of the experimental group after treatment was significantly better than that of the control group. And the sex hormone of serum testosterone, estradiol and prolactin in the experimental group were significantly better than those in the control group. The differences were statistically significant (P < 0.05). Conclusion Ziprasidone in treatment of patients with schizophrenia can significantly improve curative effects and it will not significantly affect the metabolism and hormone level of the patients. The curative effects are significant.
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