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廖国栋,蒙雪芳,蓝超越,黄大海,莫东波,苏艳飞.氨磺必利和利培酮治疗女性精神分裂症的效果及对患者糖脂代谢指标的影响[J].中国医药科学,2020,(1):73-76        基金项目:
氨磺必利和利培酮治疗女性精神分裂症的效果及对患者糖脂代谢指标的影响
Curative effects of amisulpride and risperidone in treatment of female schizophrenia patients and its effects on glucose and lipid metabolism indexes of patients
  
DOI:
中文关键词:  精神分裂症;氨磺必利;利培酮;糖脂代谢;催乳素
英文关键词:Schizophrenia;Amisulpride;Risperidone;Glucose and lipid etabolism;Prolactin
作者单位
廖国栋,蒙雪芳,蓝超越,黄大海,莫东波,苏艳飞 广西壮族自治区河池市环江爱心医院,广西河池 547100 
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中文摘要:
      [摘要] 目的 探讨氨磺必利和利培酮治疗女性精神分裂症的效果及对患者糖脂代谢指标的影响。 方法 将我院于 2018 年 1 月~ 2019 年 5 月收治的 60 例女性 SP 患者按照随机数字表法分为两组。对照组 30例采用利培酮治疗,研究组 30 例予以氨磺必利治疗。比较两组患者临床疗效、三酰甘油、胆固醇、空腹血糖、体质指数、催乳素水平以及不良反应。 结果 研究组临床总有效率高于对照组,差异有统计学意义(P < 0.05)。两组患者干预前 PANSS 评分、三酰甘油、胆固醇、空腹血糖、体质指数及催乳素水平比较,差异无统计学意义(P > 0.05),干预后两组 PANSS 评分、空腹血糖均较干预前显著降低,两组三酰甘油、胆固醇、体质指数及催乳素水平均较干预前显著升高,差异有统计学意义(P < 0.05),且两组 PANSS 评分、三酰甘油、胆固醇、体质指数比较,差异有统计学意义(P < 0.05)。研究组不良反应发生率低于对照组,差异有统计学意义(P < 0.05)。 结论 氨磺必利治疗女性 SP 相较于利培酮而言,效果更优,不良反应更低,但是对机体脂代谢影响较大。
英文摘要:
      [Abstract] Objective To explore curative effects of amisulpride and risperidone in treatment of female schizophrenia patients (SP) and its effects on glucose and lipid etabolism indexes of patients. Methods 60 female SP who were admitted and treated in our hospital from January 2018 to May 2019 were selected and they were divided into two groups according to the random number table method.30 patients in the control group were treated with risperidone while 30 patients in the study group were treated with amisulpride.The clinical curative effects,triacylglycerol,cholesterol,fasting blood glucose,body mass index,prolactin levels and adverse reactions were compared between the two groups. Results The total effective rate of clinical treatment of the study group was higher than that of the control group,and the difference was statistically significant (P < 0.05).There was no statistically significant difference in PANSS score,triglyceride,cholesterol,fasting blood glucose,body mass index and prolactin levels before intervention between the two groups (P > 0.05).The PANSS score and fasting blood glucose of the two groups were significantly lower than those before intervention.The levels of triglyceride,cholesterol,body mass index and prolactin were significantly higher than those before intervention.The differences were statistically significant (P < 0.05).There were statistically significant differences in PANSS score,triglyceride,cholesterol and body mass index between the two groups (P < 0.05).The incidence of adverse reactions in the study group was lower than that in the control group,and the difference was statistically significant (P < 0.05). Conclusion Compared with risperidone,amisulpride in treatment of female SP has better curative effects and fewer adverse reactions,but it has a great influence on the body's lipid metabolism.
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