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丁健,黄琳淇,黄转弟.热性惊厥患儿血清H2S、NSE、BDNF含量变化及FS发作相关危险因素研究[J].中国医药科学,2020,(1):13-15        基金项目:广东省东莞市社会科技发展(一般)项目 (2018507150011350)
热性惊厥患儿血清H2S、NSE、BDNF含量变化及FS发作相关危险因素研究
Study on the changes of serum H2S,NSE,BDNF levels and related risk factors of FS in children with febrile convulsion
  
DOI:
中文关键词:  热性惊厥;硫化氢;脑源性神经营养因子;神经元特异性烯醇化酶;危险因素
英文关键词:Febrile seizures;Hydrogen sulfide;Brain-derived neurotrophic factor;Neuron-specific enolase; Risk factor
作者单位
丁健,黄琳淇,黄转弟 广东省东莞市人民医院儿科,广东东莞 523059 
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中文摘要:
      [摘要] 目的 探究热性惊厥患儿血清 H2S、NSE、BDNF 含量变化及相关危险因素。 方法 选取 2017 年 1月~ 2019 年 3 月我院儿科收治的热性惊厥患儿 100 例、急性上呼吸道感染不伴有惊厥的患儿 50 例、50 例健康儿童作为研究对象。对多种高危因素进行相关性统计分析并检测三组成员血清中 H2S、NSE、BDNF 水平。 结果 FS 组患儿入院 24h 外周血 H2S 下降、NSE、BDNF 水平上升明显,与 FS 组退热 48h 后、发热组入院 24h 相比差异有统计学意义(P < 0.05)。FS 组、发热组患儿退热 48h 后与健康组比较,FS 组 NSE、BDNF水平高于发热组、健康组,差异有统计学意义(P < 0.05)。FS 组和发热组在最高体温、一级亲属有发生病史、二级亲属有发生病史产时并发症、早产等因素相比较,差异有统计学意义(P < 0.05)。 结论 FS 发作会造成患儿血清 H2S 水平下降、NSE、BDNF 的水平上升,临床上可采取相应措施以减少热性惊厥的发生。
英文摘要:
      [Abstract] Objective To investigate the changes of serum H2S,NSE and BDNF levels and related risk factors in children with febrile convulsion. Methods From January 2017 to March 2019,100 children with febrile convulsion admitted to the department of pediatrics of our hospital,50 children with acute upper respiratory tract infection without convulsion and 50 healthy children were selected as the study objects.Correlation statistical analysis was conducted for various high-risk factors and serum H2S,NSE and BDNF levels were detected of the three groups. Results In the FS group,H2S in peripheral blood decreased and NSE and BDNF levels increased significantly within 24 hours after admission,and the difference was statistically significant compared with that in the FS group after 48h of fever reduction and 24h of admission in the fever group (P < 0.05).Compared with the healthy group,NSE and BDNF levels of the FS group and the fever group were higher than those of the fever group and the healthy group 48 hours after the reduction of fever,and the difference was statistically significant (P < 0.05).There were statistically significant differences between the FS group and the fever group in the factors such as the highest body temperature,first-degree and second-degree relatives with a medical history of labor complications,and premature birth, etc.(P < 0.05). Conclusion FS attack will cause the decrease of serum H2S level and the increase of NSE and BDNF level in children.Therefore,appropriate measures can be taken clinically to reduce the occurrence of thermal convulsion.
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