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师海瑞1,2,蔡扬1,孔义华3,王显河3,吴秋阳3,梅艳3.枸橼酸铋钾与白芍总苷联用对口腔扁平苔藓患者 的疗效及CD3+、CD4+、CD8+水平的影响[J].中国医药科学,2020,(1):9-12        基金项目:
枸橼酸铋钾与白芍总苷联用对口腔扁平苔藓患者 的疗效及CD3+、CD4+、CD8+水平的影响
Curative effects of bismuth potassium citrate combined with total glucosides of paeony in treatment of patients with oral Lichen planus and its effects on CD3+,CD4+ and CD8+ Levels
  
DOI:
中文关键词:  口腔扁平苔藓;枸橼酸铋钾;白芍总苷;疗效;免疫功能
英文关键词:Oral lichen planus;Bismuth potassium citrate;Total glucosides of paeony;Curative effects;Immune function
作者单位
师海瑞1,2,蔡扬1,孔义华3,王显河3,吴秋阳3,梅艳3 1. 贵州医科大学,贵州贵阳 550004;2. 贵州医科大学第二附属医院口腔科,贵州凯里 556000;3. 贵州医科大学第二附属医院检验科,贵州凯里 556000 
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中文摘要:
      [摘要] 目的 研究枸橼酸铋钾与白芍总苷联用对口腔扁平苔藓患者的疗效及 CD3+、CD4+、CD8+水平的影响。 方法 将 2017 年 2 月 ~ 2018 年 2 月于我院接受治疗的口腔扁平苔藓患者 84 例作为观察对象。通过随机抽签法将其均分成研究组与对照组,对照组予以单独枸橼酸铋钾治疗,研究组则于对照组的基础上增用白芍总苷治疗。分别对比两组在临床疗效,治疗前后 CD3+、CD4+、CD8+水平,治疗前后疼痛情况,不良反应发生情况等方面的差异。 结果 研究组与对照组在治疗总有效率方面比较,前者更高,差异有统计学意义(P < 0.05)。治疗前研究组与对照组在 CD3+、CD4+、CD8+水平方面比较差异无统计学意义(均 P > 0.05);治疗后研究组 CD3+、CD4+、CD8+水平相比对照组较高,CD8+水平相比对照组较低,差异有统计学意义(均P < 0.05)。治疗后 1、3 个月研究组与对照组在 VAS 评分方面比较,前者更低,差异有统计学意义(均P < 0.05)。研究组与对照组在腹泻、麻木、灼痛发生率方面比较差异无统计学意义(均 P > 0.05)。 结论枸橼酸铋钾与白芍总苷联用治疗口腔扁平苔藓可获得较为理想的疗效,同时有利于改善患者的免疫功能,减轻患者疼痛,安全性较好,值得临床推广应用。
英文摘要:
      [Abstract] Objective To study curative effects of bismuth potassium citrate combined with total glucosides of paeony in treatment of patients with oral lichen planus and its effects on CD3+,CD4+ and CD8+ levels. Methods 84 patients with oral lichen planus who were treated in our hospital from February 2017 to February 2018 were selected as observative objects.They were divided into study group and control group by random lottery method.The control group was treated with bismuth potassium citrate alone while the study group was treated with total glucosides of paeony on basis of the control group.The clinical curative effects,levels of CD3+,CD4+ and CD8+ before and after treatment,pain before and after treatment and adverse reactions were compared between two groups. Results Compared with the control group in terms of total effective rate of treatment, the former group was higher and the difference was statistically significant (P < 0.05).There was no significant difference in the levels of CD3+,CD4+,and CD8+ between the study group and the control group before treatment,and the differences were not statistically significant (all P > 0.05).After treatment,the levels of CD3+,CD4+,and CD8+ in the study group were higher than those in the control group,and the levels of CD8+ were lower than in the control group.The difference was statistically significant (all P < 0.05).The VAS scores of the study group and the control group were lower at 1 month and 3 months after treatment,and the former was lower,and the difference was statistically significant (all P < 0.05).There was no significant difference in the incidence of diarrhea,numbness and burning pain between the study group and the control group,and the difference was not statistically significant (all P > 0.05). Conclusion Bismuth potassium citrate combined with total glucosides of paeony in treatment of patients with oral lichen planus can achieve more ideal curative effects.At the same time,it is beneficial to improve the immune function and reduce the pain of the patients.It has good safety and is worthy of clinical promotion and application.
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