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黎巧茹1,邹亚伟2▲,赖文英1,林春燕1,李丽羽1.CD4+细胞与CD8+细胞比值与新生儿缺氧缺血性脑病的相关性分析[J].中国医药科学,2020,(1):6-8        基金项目:广东省自然科学基金(2016A030313654)
CD4+细胞与CD8+细胞比值与新生儿缺氧缺血性脑病的相关性分析
Analysis on correlation between the ratio of CD4+ cells to CD8+cells and neonatal hypoxic-ischemic encephalopathy
  
DOI:
中文关键词:  新生儿缺氧缺血性脑病;淋巴细胞;T 淋巴细胞亚群;CD4+T 淋巴细胞;CD8+T 淋巴细胞
英文关键词:Neonatal hypoxic-ischemic encephalopathy;Lymphocyte;T lymphocyte subsets;CD4+T lymphocyte;CD8+T lymphocyte
作者单位
黎巧茹1,邹亚伟2▲,赖文英1,林春燕1,李丽羽1 1. 广东省中山市人民医院普通儿科,广东中山 528400;2. 广州医科大学附属第一医院儿科,广东广州 510000 
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中文摘要:
      [摘要] 目的 明确 CD4+细胞与 CD8+细胞比值与新生儿缺氧缺血性脑病病情的相关性。方法 选取 2015 年10 月~ 2018 年 6 月中山市人民医院新生儿科住院的 60 例 HIE 患儿及同期我院产科出生正常新生儿 73例。应用流式细胞仪测定血 CD3+、CD4+、CD8+细胞及 CD4+/CD8+比值。 结果 HIE 患儿 T 细胞亚群的表达均明显低于正常新生儿(P 均< 0.05);重度 HIE 患儿 CD3+、CD4+细胞及 CD4+/CD8+比值明显均低于中度HIE 患儿(P 均< 0.05),中度 HIE 患儿 CD3+、CD4+细胞及 CD4+/CD8+ 比值明显均低于轻度 HIE 患儿(P 均< 0.05),而不同分度 HIE 的 CD8+细胞则无统计学差异(P > 0.05);CD3+、CD4+及 CD4+/CD8+与 HIE 病情分度均呈负相关(P 均< 0.05)。结论 CD4+/CD8+比值与 HIE 新生儿的病情危重程度密切相关,可作为患儿病情严重程度的有效预测指标。
英文摘要:
      [Abstract] Objective To determine the correlation between the ratio of CD4+ cells to CD8+ cells and neonatal hypoxic-ischemic encephalopathy. Methods 60 neonates with HIE who were hospitalized in department of neonatology in Zhongshan People’s Hospital and 73 normal neonates who were born in department of obstetrics in our hospital from October 2015 to June 2018 were selected.CD3+,CD4+,CD8+cells and the ratio of CD4+/CD8+ were measured by flow cytometry. Results The expression of T lymphocyte subsets in patient with HIE was significantly lower than that in normal newborns(P < 0.05).The levels of CD3+ and CD4+ and CD4+/CD8+ ratio in patient with severe HIE were significantly lower than those in patient with moderate HIE(P < 0.05).The levels of CD3+,CD4+cells and CD4+/CD8+ ratio in patient with moderate HIE was significantly lower than those in patient with mild HIE (P < 0.05).But the CD8+ cells in different grades of HIE had no statistically significant difference(P > 0.05).CD3+,CD4+ and CD4+/CD8+ were negatively correlated with the severity of HIE(P < 0.05). Conclusion The ratio of CD4+/CD8+is closely related to the severity of neonates with HIE, which can be used as an effective predictor of the severity of neonates.
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