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陆积新1,李近都2,潘兴寿3,李天资3,邹才华3,曾德创3,梁烨3▲.石斛多糖对SHR晚期糖基化终产物代谢变化及其与炎症因子的关系[J].中国医药科学,2020,(1):1-5        基金项目:国家自然科学基金(81060028);广西重大专项基金(桂科重 1598005-9,桂科攻 1355005-3-7);广西卫生基金(GXZC1242)
石斛多糖对SHR晚期糖基化终产物代谢变化及其与炎症因子的关系
Effects of dendrobium polysaccharides on metabolic changes of SHR advanced glycation end products and its relationship with inflammatory factors
  
DOI:
中文关键词:  石斛多糖;炎症因子;晚期糖基化终产物;晚期糖基化终产物受体
英文关键词:Dendrobium polysaccharides;Inflammatory factors;Advanced glycosylation end products (AGE);Receptor for advanced glycation end product
作者单位
陆积新1,李近都2,潘兴寿3,李天资3,邹才华3,曾德创3,梁烨3▲ 1. 广西壮族自治区贵港市覃塘区人民医院神经内科,广西贵港 537121;2. 广西医科大学附属肿瘤医院肝胆外科,广西南宁 530000;3. 右江民族医学院附属医院心血管疾病研究所,广西百色 533000 
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中文摘要:
      [摘要] 目的 探讨石斛多糖对自发性高血压大鼠(SHR)炎症因子和晚期糖基化终产物代谢的效果及其剂量。 方法 提取石斛多糖,将 SHR 随机分为对照组、低剂量组、中剂量组和高剂量组四组,对照组给开水,低剂量组、中剂量组和高剂量组分别给石斛多糖 100、300、500mg/d,干预 2 个月,比较干预后各组肿瘤坏死因子(TNF-α),白细胞介素(IL)-6,IL-10,晚期糖基化终产物(AGE),可溶性 AGE 受体(sRAGE)和全长 AGE 受体(RAGE)mRNA 水平。 结果 与对照组比较,低剂量组 TNF-α 水平比较,差异有统计意义(P < 0.05),中剂量组 TNF-α、IL-6 和 IL-10 水平差异有统计意义(P < 0.05),高剂量组 TNF-α、IL-6和 IL-10 水平差异有统计意义(P < 0.05)。低剂量组 sRAGE 水平差异有统计意义(P < 0.05),中剂量组sRAGE 和 RAGE mRNA 水平比较,差异有统计意义(P < 0.05),高剂量组 AGE、sRAGE 和 RAGE mRNA 水平比较,差异有统计意义(P < 0.05)。石斛多糖能够有效缓解 SHR 的炎症因子和晚期糖基化终产物代谢紊乱。其改善 TNF-α、IL-6、IL-10、AGE、sRAGE 和 RAGE mRNA 的作用有剂量效应关系,纠正 SHR 炎症因子功能紊乱的有效剂量为 300mg/d;纠正 SHR 晚期糖基化终末产物及其受体功能紊乱的有效剂量为500mg/d。 结论 石斛多糖可有效缓解 SHR 的炎症因子功能紊乱,降低 AGE 水平,提高 sRAGE 水平,降低RAGE 基因的活化,对缓解 SHR 的血管重塑有积极的作用。其药效有剂量效应关系,中等剂量可有效改善炎症症状,高剂量能改善 AGE 及其受体症状。
英文摘要:
      [Abstract] Objective To explore effects of dendrobium polysaccharides on metabolic changes of spontaneous hypertensive rats (SHR) inflammatory factors and advanced glycation end products metabolism and its relationship with its dosage. Methods Dendrobium polysaccharides was extracted,and SHR was randomly divided into the control group,low dose group,medium dose group and high dose group.The control group was given boiled water,and the lowdose group,the middle-dose group and the high-dose group were given dendrobium polysaccharide of 100,300,500mg/d, respectively.After 2 months of intervention,tumor necrosis factor (TNF-α),interleukin (IL)-6,IL-10,mRNA levels of advanced glycation end products (AGE),soluble receptor for AGE (sRAGE) and full-length of receptor for AGE (RAGE) were compared between two groups after intervention. Results Compared with the control group,the difference of TNF-α levels in the low dose group was statistically significant (P < 0.05).Compared with the control group,the levels of TNF-α,IL-6 and IL-10 in the middle dose group were statistically significant (P < 0.05).Compared with the control group,the levels of TNF-α,IL-6 and IL-10 in the high-dose group were statistically significant (P < 0.05).The difference of sRAGE levels in the low dose group was statistically significant (P < 0.05).The difference of sRAGE and RAGE mRNA levels in the middle dose group was statistically significant (P < 0.05).The difference of AGE,sRAGE and RAGE mRNA levels in the high dose group was statistically significant (P < 0.05).Dendrobium polysaccharide can effectively alleviate the inflammatory factors of SHR and the metabolic disorders of advanced glycation end products.It has a dose-effect relationship between the effects of improving TNF-α,IL-6,IL-10,AGE,sRAGE and RAGE mRNA.The effective dose to correct dysfunction of SHR inflammatory factors was 300mg/d.The effective dose to correct dysfunction of advanced glycation end products and their receptors in SHR was 500 mg/d. Conclusion Dendrobium polysaccharide can effectively alleviate the dysfunction of inflammatory factors in SHR,reduce AGE level,increase sRAGE level,reduce the activation of RAGE gene,which has a positive effect on relieving vascular remodeling of SHR.Its efficacy has a dose-effect relationship.Medium dose can effectively improve the symptoms of inflammation and high dose can improve the symptoms of AGE and its receptors.
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