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吴昱冶,黄美玲.晚期肺癌患者血清肿瘤标志物与凝血功能变化的临床研究[J].中国医药科学,2019,(16):202-204        基金项目:
晚期肺癌患者血清肿瘤标志物与凝血功能变化的临床研究
Clinical study on the changes of serum tumor markers and coagulation function in patients with advanced lung cancer
  
DOI:
中文关键词:  肺癌;酶联免疫吸附试验;血清肿瘤标志物;凝血功能
英文关键词:Lung cancer;Enzyme linked immunosorbent assay;Serum tumor markers;Coagulation function
作者单位
吴昱冶,黄美玲 广东医科大学,广东湛江 524000 
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中文摘要:
      [摘要] 目的 探讨晚期肺癌患者血清肿瘤标志物与凝血功能变化的临床研究。 方法 选取 2016 年 3 月~ 2018年 3 月我院收治的原发性肺癌患者 87 例纳入观察组,另取同时期我院体检中心 50 例健康人群纳入对照组。使用酶联免疫吸附试验对晚期肺癌患者血清癌胚抗原(CEA)、糖类抗原 199(CA199)和糖类抗原 125(CA125)水平进行测定。并使用全自动血凝分析仪对活化部分凝血酶时间(APTT)、凝血酶原时间(PT)和纤维蛋白原(FIB)进行测定。分析晚期肺癌患者血清肿瘤标志物与上述凝血功能指标的相关性。 结果 两组患者相比,观察组血清 APTT 和 PT 水平低于对照组患者,而 FIB 水平高于对照组患者(P < 0.05)。此外,观察组患者血清 CEA、CA199 和 CA125 水平均高于对照组患者(P < 0.05)。Pearson 相关性分析结果显示,晚期肺癌患者血清 CEA、CA199、CA125 与血清 APTT、PT 水平呈正相关,而与 FIB 水平呈负相关(P< 0.05)。 结论 晚期肺癌患者血清 CEA、CA199、CA125 与 APTT、PT 水平呈正相关,而与 FIB 水平呈负相关。上述血清肿瘤标志物与凝血功能指标均能够用于晚期肺癌患者病情变化的评估和监测,同时还有助于患者并发深静脉血栓风险的预测,对于该类患者进一步诊疗措施的制定和改善预后具有一定临床价值。
英文摘要:
      [Abstract] Objective To explore the changes of serum tumor markers and coagulation function in patients with advanced lung cancer. Methods 87 patients with primary lung cancer admitted to our hospital from March 2016 to March 2018 were selected as the observation group,and 50 healthy people from the physical examination center of our hospital during the same period were selected as the control group. Serum levels of carcino embryonic antigen(CEA),carbohydrate antigen 199(CA199)and carbohydrate antigen 125(CA125)in patients with advanced lung cancer were determined by ELISA.The activated partial thromboplastin time(APTT),prothrombin time(PT)and fibrinogen(FIB)were measured by Automatic Coagulation analyzer.The correlations between serum tumor markers and the above coagulation function indicators in patients with advanced lung cancer were analyzed. Results The serum APTT and PT levels in the observation group were lower than the control group,while FIB levels were higher than the control group(P < 0.05).In addition,the levels of serum CEA,CA199 and CA125 in the observation group were higher than the control group(P < 0.05).Pearson correlation analysis showed that serum CEA,CA199 and CA125 were positively correlated with serum APTT and PT levels,but negatively correlated with FIB levels in patients with advanced lung cancer(P < 0.05). Conclusion Serum CEA,CA199 and CA125 levels in patients with advanced lung cancer were positively correlated with APTT and PT levels,but negatively correlated with FIB levels.The above serum tumor markers and coagulation function indicators can be used to evaluate and monitor the condition changes of patients with advanced lung cancer,and also help to predict the risk of deep venous thrombosis,which has a certain clinical value for the formulation of further diagnosis and treatment measures and improvement of prognosis .
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