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许宏俊,周春山,黄楚丽,赖汉齐,陈兰香.血小板和淋巴细胞比率与颈动脉粥样硬化微栓子形成之间的关系[J].中国医药科学,2019,(16):187-190        基金项目:
血小板和淋巴细胞比率与颈动脉粥样硬化微栓子形成之间的关系
Relationship between platelet and lymphocyte ratio and formation of carotid atherosclerosis microemblic signals
  
DOI:
中文关键词:  颈动脉粥样硬化;血小板和淋巴细胞比率;微栓子;不稳定斑块
英文关键词:Carotid atherosclerosis;Platelet and lymphocyte ratio;Microemblic signal;Unstable plaques
作者单位
许宏俊,周春山,黄楚丽,赖汉齐,陈兰香 广东省普宁华侨医院,广东普宁 515300 
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中文摘要:
      [摘要] 目的 探讨颈动脉粥样硬化微栓子(MES)的形成与患者外周血血小板和淋巴细胞比率(PLR)的关系。 方法 自 2018 年 1 ~ 6 月,从我院心内超声科确诊的高血压合并颈动脉粥样硬化患者中筛选出不稳定性斑块患者 135 例,监测每个患者外周血 PLR 的值,应用经颅彩色多普勒检查鉴定,根据检测结果分为 MES 阳性组和阴性组患者各 73 例和 62 例。 结果 MES 阳性组和阴性组基线差异主要表现在吸烟史(P=0.034)、低密度脂蛋白(P=0.055)和总胆固醇含量(P=0.011)。MES 阳性组患者外周血 PLR 值显著高于 MES 阴性组[(197±73)vs (121±55),P < 0.001]。根据 PLR 的中位值(152)将 135 例患者被分成高 PLR 组和低 PLR 组,亚组分析显示 MES 阳性组中高 PLR 的患者比例显著大于 MES 阴性组(61.64% vs 37.10%,P=0.004)。Spearman 相关性分析显示 PLR 的高低同低密度脂蛋白(r=0.403,P=0.018)、总胆固醇(r=0.447,P=0.007、 甘油三酯(r=0.387,P < 0.001)、同型半光氨酸(r=0.536,P < 0.001)及 IMT 厚度(r=0.572,P < 0.001)正相关。 结论 外周血 PLR 值的大小同颈动脉粥样硬化 MES 的形成密切相关,或可作为分子标记物应用于斑块发生发展的监测。
英文摘要:
      [Abstract] Objective To explore the relationship between the formation of carotid atherosclerosis microemblic signals (MES) and the peripheral blood platelet and lymphocyte ratio (PLR). Methods From January to June 2018,135 patients with unstable plaque were screened from patients with hypertension complicated with carotid atherosclerosis diagnosed by department of intracardiac ultrasound in our hospital.The value of peripheral blood PLR was monitored in each patient and it was tested by transcranial color Doppler examination.According to the results of the test,patients were divided into MES positive group with 73 cases and MES negative group with 62 cases. Results Baseline differences between the MES positive and negative groups were mainly in the smoking history (P=0.034),low-density lipoprotein (P=0.055) and total cholesterol content (P=0.011).The PLR value of peripheral blood in the MES positive group was significantly higher than that in the MES negative group [(197±73) vs (121±55),P < 0.001].According to the median value of PLR (152),135 patients were divided into high PLR group and low PLR group.Subgroup analysis showed that the proportion of patients with high PLR in MES positive group was significantly larger than that in MES negative group (61.64% vs 37.10%,P=0.004).Spearman correlation analysis showed that PLR values was positively related with low density lipoprotein (r=0.403,P=0.018),total cholesterol (r=0.447,P=0.007), triglyceride (r=0.387, P< 0.001),homocysteine (r=0.536,P< 0.001) and IMT thickness (r=0.572,P < 0.001). Conclusion The PLR value of peripheral blood is closely related to the formation of carotid atherosclerosis MES,or it can be used as a molecular marker to monitor the development of plaque.
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