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孙运涛.多种指标在儿童上呼吸道感染早期诊断中的临床意义[J].中国医药科学,2019,(16):126-129        基金项目:
多种指标在儿童上呼吸道感染早期诊断中的临床意义
Clinical significance of multiple indexes in early diagnosis of upper respiratory tract infection in children
  
DOI:
中文关键词:  血常规;C- 反应蛋白;降钙素原;血清淀粉样蛋白 A;儿童上呼吸道感染;早期诊断
英文关键词:Blood routine examination;C-reactive protein;Procalitonin;Serum amyloid A;Upper respiratory tract infection in children;Early diagnosis
作者单位
孙运涛 广东省中山市东凤人民医院,广东中山 528400 
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中文摘要:
      [摘要] 目的 探究白细胞计数(WBC)、中性粒细胞比例(NC)、血小板计数(PLT)、C- 反应蛋白(CRP)、降钙素原(PCT)以及血清淀粉样蛋白 A(SAA)等多种指标联合检测在儿童上呼吸道感染早期诊断中的临床意义。 方法 将本院 2018 年 1 ~ 12 月间收治上呼吸道感染患儿 100 例作为观察组,同期进行健康体检儿童50 例作为对照组,观察组患儿依据感染类型不同分为病毒亚组(n=46)与细菌亚组(n=54),分别检测并对比各组受检儿童的 WBC、NC、PLT、CRP、PCT 以及 SAA 等 6 项指标的差异。 结果 观察组患儿 WBC、NC、PLT、CRP、PCT 以及 SAA 指标水平均显著高于对照组儿童,差异有统计学意义(P < 0.05);细菌亚组患儿WBC、NC、PLT、CRP、PCT 以及 SAA 指标水平相比病毒亚组患儿,差异有统计学意义(P < 0.05);PCT 指标诊断的符合率、阳性预测值、阴性预测值、敏感度以及特异度在各指标中最高,各指标对比差异有统计学意义(P < 0.05)。 结论 在儿童上呼吸道感染早期诊断中,WBC、NC、PLT、CRP、PCT 以及 SAA 等多指标联合检测可较准确发挥诊断与鉴别诊断作用,PCT 指标在儿童上呼吸道感染早期诊断的效能最高。
英文摘要:
      [Abstract] Objective To explore the clinical significance of combined detection of white blood cell count (WBC),neutrophils ratio (NC),platelet count (PLT),C-reactive protein (CRP),procalitonin (PCT) and serum amyloid A (SAA) in the early diagnosis of upper respiratory tract infection in children. Methods 100 children with upper respiratory tract infection who were admitted and treated in our hospital from January to December 2018 were selected as the observation group.50 children who underwent physical examinations during the same period were selected as the control group.Children in the observation group were divided into the virus subgroup (n=46) and the bacterial subgroup (n=54) according to the type of infection.The differences of six indexes including WBC,NC,PLT,CRP,PCT and SAA of children of two groups were detected and compared. Results The levels of WBC,NC,PLT,CRP,PCT and SAA in the observation group were significantly higher than those in the control group.The difference was statistically significant (P < 0.05).The differences in levels of WBC,NC,PLT,CRP,PCT and SAA in bacterial subgroup were statistically significantly different from those in virus subgroup (P < 0.05).The coincidence rate,positive predictive value,negative predictive value,sensitivity and specificity of PCT were the highest among all the indexes.There was statistically significant difference among those indexes (P < 0.05). Conclusion In the early diagnosis of upper respiratory tract infection in children,the combined detection of WBC,NC,PLT,CRP,PCT and SAA can play a more accurate role in diagnosis and differential diagnosis.PCT is the most effective index in the early diagnosis of upper respiratory tract infection in children.
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