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邓燕群1,刘翠玉2,尹志华1,张允奇1,罗秀霞1.多囊卵巢综合征患者血清中IL-33、sST2及AMH水平表达及临床意义[J].中国医药科学,2019,(16):116-119        基金项目:
多囊卵巢综合征患者血清中IL-33、sST2及AMH水平表达及临床意义
Expression levels of serum IL-33, sST2 and AMH in patients with polycystic ovary syndrome and its clinical significance
  
DOI:
中文关键词:  多囊卵巢综合征;白细胞介素 -33;可溶性受体 ST2;抗苗勒氏管激素
英文关键词:Polycystic ovarian syndrome;Interleukin-33;Soluble receptor ST2;Anti-Mullerian hormone
作者单位
邓燕群1,刘翠玉2,尹志华1,张允奇1,罗秀霞1 1. 深圳市福田区风湿病专科医院检验科,广东深圳 518040;2. 中山大学附属第八(福田)医院检验科,广东深圳 518040 
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中文摘要:
      [摘要] 目的 了解白细胞介素 -33(IL-33)及其可溶性受体 ST2(sST2)和抗苗勒氏管激素(AMH)在多囊卵巢综合征(PCOS)患者血清中的变化情况,为 PCOS 患者的诊疗提供理论参考依据。 方法 收集 2016年 3 月~ 2018 年 6 月来医院就诊并确诊为 PCOS 患者 192 例为实验组,并选择同期未孕健康孕龄女性 120例为对照组,采用酶联免疫吸附法(ELISA)检测血清中 IL-33 和 sST2 水平,采用化学发光免疫法检测血清中 AMH 水平,并对检测结果进行统计分析。 结果 120 例健康未孕女性血清中 IL-33、sST2 及 AMH水 平 分 别 为(26.75±8.62)pg/mL、(0.06±0.04)μg/mL 和(5.16±1.73)ng/mL,192 例 PCOS 患 者 分 别 为(231.73±104.26)pg/mL、(3.24±1.52)μg/mL 和(10.65±3.91)ng/mL,明显高于对照组,差异有统计学意义(t=4.0935 ~ 21.9506,P < 0.05)。PCOS 患者血清中 IL-33 与 sST2、IL-33 与 AMH 及 sST2 与 AMH水平之间均呈正相关性,相关系数 r=0.9145、0.6252 及 0.7168,差异均有统计学意义(P < 0.05)。各年龄组 PCOS 患者血清中 IL-33、sST2 及 AMH 水平之间差异均统计学意义(F=2.7061,F=3.5024,F=6.0835,P < 0.05),且随着年龄的增长呈逐步下降趋势。 结论 PCOS 患者血清中 IL-33、sST2 及 AMH 水平明显高于正常健康未孕女性,且各指标之间均呈正相关性,对 PCOS 的诊疗具有一定的理论参考依据,值得临床推广应用。
英文摘要:
      [Abstract] Objective To understand the changes of interleukin-33 (IL-33),its soluble receptor ST2 (sST2) and anti-Mullerian hormone (AMH) in the serum of patients with polycystic ovary syndrome (PCOS) so as to provide theoretical basis for the diagnosis and treatment of PCOS patients. Methods 192 patients who were diagnosed as PCOS p in our hospital from March 2016 to June 2018 were selected as the experimental group.120 healthy women of gestational age without pregnancy during the same period were selected as the control group.Serum IL-33 and sST2 levels were measured by enzyme-linked immunosorbent assay (ELISA) and serum AMH levels were detected by chemiluminescence immunoassay.The test results were analyzed statistically. Results Serum IL-33,sST2 and AMH levels in 120 healthy non-pregnant women were (26.75±8.62)pg/mL,(0.06±0.04)ug/mL and (5.16±1.73)ng/mL,respectively.Those of 192 PCOS patients were respectively(231.73±104.26)pg/mL,(3.24±1.52)ug/mL and (10.65±3.91)ng/mL,significantly higher than those of the control group.The difference was statistically significant (t=4.0935-21.9506,P < 0.05).There were positive correlations between serum IL-33 and sST2,between IL-33 and AMH and between sST2 and AMH.Correlation coefficients r=0.9145,0.6252 and 0.7168,respectively,with statistically significant differences (P < 0.05).Serum IL-33,sST2 and AMH levels of PCOS patients in different age groups were statistically significant (F=2.7061,3.5024,6.0835,P < 0.05).Serum levels of IL-33,sST2 and AMH in PCOS patients showed a gradual decline with the increase of age. Conclusion Serum levels of IL-33,sST2 and AMH in PCOS patients were significantly higher than those in healthy women without pregnancy and all the indexes are positively correlated.It has certain theoretical reference basis for the diagnosis and treatment of PCOS,which is worthy of clinical promotion and application.
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