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杨东群1,张迎愉2,周文娟1.妊娠期间筛查甲状腺功能相关指标对妊娠糖尿病的风险预测价值[J].中国医药科学,2019,(16):113-115        基金项目:
妊娠期间筛查甲状腺功能相关指标对妊娠糖尿病的风险预测价值
Values of screening thyroid function related indexes during pregnancy in the risk prediction of gestational diabetes mellitus
  
DOI:
中文关键词:  甲状腺功能减退;妊娠糖尿病;妊娠结局;围产儿结局
英文关键词:Hypothyroidism;Gestational diabetes mellitus;Pregnancy outcome;Perinatal outcome
作者单位
杨东群1,张迎愉2,周文娟1 1. 广东省惠州市妇幼保健计划生育服务中心产科,广东惠州 516000;2. 广东省惠州市中心人民医院妇产科,广东惠州 516000 
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中文摘要:
      [摘要] 目的 探讨妊娠期间筛查甲状腺功能相关指标对妊娠糖尿病(GDM)的风险预测价值。 方法 选取2017 年 1 年~ 2018 年 3 月在我院进行产检的妊娠糖尿病孕妇 120 例,根据其是否合并甲状腺功能减退分为甲减组 60 例和对照组 60 例,比较两组患者的甲状腺功能、血糖指标及不良妊娠和围产儿结局。结果与对照组比较,甲减组患者的 TSH 和 TPOAb 均显著升高,而 FT3 和 FT4 则显著降低,差异具有统计学意义(P < 0.05);与对照组相比,甲减组患者的 FPG、2h PG、HOMA-IR 及 HbA1C 均显著升高,差异具有统计学意义(P < 0.05);甲减组患者不良妊娠和围产儿结局的发生率为 19 例(31.6%),对照组患者不良妊娠和围产儿结局的发生率为 6 例(10.00%),差异具有统计学意义(P < 0.05)。 结论 甲状腺功能减退能够导致妊娠期糖尿病患者出现糖代谢紊乱,并提高患者产后出血、胎膜早破、宫内生长受限等不良妊娠和围产儿结局的发生率,临床应密切监测,并给予及时干预。
英文摘要:
      [Abstract] Objective To explore values of screening thyroid function related indexes during pregnancy in the risk prediction of gestational diabetes mellitus. Methods 120 pregnant women with gestational diabetes mellitus (GDM) who underwent production inspection in our hospital from January 2017 to March 2018 were selected.According to whether or not combined with hypothyroidism,the patients were divided into hypothyroidism group (60 cases) and the control group (60 cases).The thyroid function,blood glucose index,adverse pregnancy and perinatal outcomes were compared between the two groups. Results Compared with the control group,the thyroid stimulating hormone (TSH) and thyroid peroxidase antibody (TPOAb) of the hypothyroidism group were significantly increased,but the FT3 and FT4 were significantly decreased.The difference was statistically significant (P < 0.05).Compared with the control group,FPG,2h PG,HOMA-IR and HbA1C of the hypothyroidism group were significantly increased,and the difference was statistically significant (P < 0.05).The incidence of the adverse pregnancy and perinatal outcomes of the hypothyroidism group was 19 cases (31.6%) while the incidence of the adverse pregnancy and perinatal outcomes of the control group was 6 cases (10.00%).The difference was statistically significant (P < 0.05). Conclusion Hypothyroidism can lead to glucose metabolic disorder in patients with gestational diabetes mellitus,improve the incidence of pregnancy such as postpartum hemorrhage and premature rupture of membranes and fetal growth restriction and perinatal outcomes,which should be closely monitored in clinical practice and given timely intervention.
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